In addition to affecting respiration and vascular tone, deviations from normal CO 2 alter pH,
consciousness, and seizure propensity. Outside the brainstem, however, the mechanisms by …

The Delphinium alkaloids methyllycaconitine (MLA), nudicauline, 14-deacetylnudicauline (14-DN),
barbinine, and deltaline were investigated for their effects on neuromuscular …

Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported
to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR). Although many …

The pharmacology of nicotinic receptor-mediated seizures was investigated in C3H mice.
Eleven nicotinic agonists and six antagonists were administered centrally (icv). Epibatidine …

Nicotine-stimulated 86 Rb + efflux and [ 3 H]cytisine binding, both of which seem to measure
the nicotinic acetylcholine receptor, composed of α4 and β2 subunits, were assessed in …

BACKGROUND AND PURPOSE Tobacco and alcohol are often co‐abused producing
interactive effects in the brain. Although nicotine enhances memory while ethanol impairs it, …

In a recent study, we reported that a restriction fragment length polymorphism associated with
the α 4 nicotinic receptor gene (Chrna4) may play a role in regulating differential sensitivity …

Metaplasticity describes the stabilization of synaptic strength such that strong synapses are
likely to remain strong while weak synapses are likely to remain weak. A potential …

A salient feature of prefrontal cortex organization is the vast diversity of cell types that support
the temporal integration of events required for sculpting future responses. A major obstacle …

The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist
of ionotropic glutamate receptors. Within the last decade several reports have been …