Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …

ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl
cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation …

Endocannabinoids are released after brain injury and believed to attenuate neuronal damage
by binding to CB 1 receptors and protecting against excitotoxicity. Such excitotoxic brain …

Oxidative stress, a risk factor for several cardiovascular disorders, interferes with the NO/sGC/cGMP
signalling pathway through scavenging of NO and formation of the strong …

Soluble guanylate cyclase (sGC), a heterodimeric hemeprotein, is the only receptor for the
biological messenger nitric oxide (NO) identified to date and is intimately involved in various …

Nitric oxide (NO) is an essential vasodilator. In vascular diseases, oxidative stress attenuates
NO signaling by both chemical scavenging of free NO and oxidation and downregulation of …

Since decades it is known that the activity of cells of the immune system is severely dysregulated
in microgravity, however, the underlying molecular aspects have not been elucidated …

The influenza surface glycoprotein neuraminidase (NA) is essential for the efficient spread
of the virus. Antiviral drugs such as Tamiflu (oseltamivir) and Relenza (zanamivir) that inhibit …

Human telomerase plays an important role in the cancerogenesis as it is up-regulated in 80–90%
of malignant tumors. Thus, it is considered as a potential cancer marker and relevant …

Objective Traumatic brain injury is a major global public health problem for which specific
therapeutic interventions are lacking. There is, therefore, a pressing need to identify innovative …