User profiles for Piruthivi Sukumar

Piruthivi Sukumar

University of Leeds
Verified email at leeds.ac.uk
Cited by 2927

TRPC channel activation by extracellular thioredoxin

SZ Xu, P Sukumar, F Zeng, J Li, A Jairaman, A English… - Nature, 2008 - nature.com
Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are
a large family of multimeric cation channels that act, or putatively act, as sensors of one or …

[HTML][HTML] Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

…, K Cuthbertson, PD Baxter, R Foster, P Sukumar… - Nature …, 2017 - nature.com
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Pregnenolone sulphate-and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction

J Naylor, J Li, CJ Milligan, F Zeng, P Sukumar… - Circulation …, 2010 - Am Heart Assoc
Rationale: Transient receptor potential melastatin (TRPM)3 is a calcium-permeable ion
channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin …

Nox2 NADPH oxidase has a critical role in insulin resistance–related endothelial cell dysfunction

P Sukumar, H Viswambharan, H Imrie, RM Cubbon… - Diabetes, 2013 - Am Diabetes Assoc
Insulin resistance is characterized by excessive endothelial cell generation of potentially
cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH oxidase (…

A Sphingosine-1–phosphate-activated calcium channel controlling vascular smooth muscle cell motility

SZ Xu, K Muraki, F Zeng, J Li, P Sukumar… - Circulation …, 2006 - Am Heart Assoc
In a screen of potential lipid regulators of transient receptor potential (TRP) channels, we
identified sphingosine-1–phosphate (S1P) as an activator of TRPC5. We explored the …

[HTML][HTML] Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation

A Cheong, AJ Bingham, J Li, B Kumar, P Sukumar… - Molecular cell, 2005 - cell.com
Induction of K Ca 3.1 (IKCa) potassium channel plays an important role in vascular smooth
muscle cell proliferation. Here, we report that the gene encoding K Ca 3.1 (KCNN4) contains …

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis

…, A Abbas, H Viswambharan, A Aziz, P Sukumar… - Diabetes, 2012 - Am Diabetes Assoc
Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are associated
with insulin resistance, diabetes, and cardiovascular disease. We investigated whether …

[HTML][HTML] Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity

…, LC Morley, TS Futers, P Sukumar… - The Journal of …, 2022 - Am Soc Clin Investig
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial
response to fluid flow. Here we reveal an important role in the control of capillary density…

Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin

P Sukumar, A Sedo, J Li, LA Wilson… - Circulation …, 2012 - Am Heart Assoc
Rationale: Calcium entry is pivotal in the heart and blood vessels, but its significance and
mechanisms in adipose tissue are largely unknown. An important factor produced by …

Robotic multiwell planar patch-clamp for native and primary mammalian cells

CJ Milligan, J Li, P Sukumar, Y Majeed, ML Dallas… - Nature protocols, 2009 - nature.com
Robotic multiwell planar patch-clamp has become common in drug development and safety
programs because it enables efficient and systematic testing of compounds against ion …