The adenylate cyclase system, which consists of a catalytic moiety and regulatory guanine
nucleotide-binding proteins, provides the effector mechanism for the intracellular actions of …

LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated
in a variety of inflammatory responses, including asthma, arthritis and psoriasis 1,2 . …

The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras
p21) share biochemical and structural properties with other guanine nucleotide-binding …

The structure and expression of the c-myc oncogene were examined in 29 primary human
colon adenocarcinomas. Dot blot hybridization of total RNA showed that 21 tumors (72%) had …

Inhibition of kinesin spindle protein (KSP) is a novel mechanism for treatment of cancer with
the potential to overcome limitations associated with currently employed cytotoxic agents. …

… Samples were not pretreated with a reducing agent prior to electrophoresis on an acid
urea … the cDNA library was rescreened with oligonucleotides corresponding to the signal …

The enzyme 5-lipoxygenase (5-LO) catalyzes the first two reactions in the pathway leading
to the formation of leukotrienes from arachidonic acid. Leukotrienes are potent arachidonic …

The protease of human immunodeficiency virus has been expressed in Escherichia coli and
purified to apparent homogeneity. Immunoreactivity toward anti-protease peptide sera …

Aspartyl (asparaginyl) beta-hydroxylase which specifically hydroxylates 1 Asp or Asn
residue in certain epidermal growth factor-like domains of a number of proteins, has been …

Revised Manuscript Received February 18, 1993 abstract: We have isolated cDNAs
encoding the a and/? subunits of human farnesyl-protein transferase (FPTase). The proteins …