New methods for the synthesis of glycosides and oligosaccharides—are there alternatives to the Koenigs‐Knorr method?[New synthetic methods (56)]

RR Schmidt - Angewandte Chemie International Edition in …, 1986 - Wiley Online Library
Glycoproteins, glycolipids, and glycophospholipids (glycoconjugates) are components of
membranes. The oligosaccharide residue is responsible for intercellular recognition and …

Synthetic Lipoteichoic Acid from Staphylococcus aureus Is a Potent Stimulus of Cytokine Release

…, A Stadelmaier, A Geyer, RR Schmidt… - The Journal of …, 2002 - rupress.org
We recently purified lipoteichoic acid (LTA) from Staphylococcus aureus to more than 99%
purity by a novel preparation method and deduced its structure with the first nuclear magnetic …

New principles for glycoside‐bond formation

X Zhu, RR Schmidt - Angewandte Chemie International Edition, 2009 - Wiley Online Library
… Beside the solvent, the nature of the counteranion in the catalyst has a major influence on
the stereoselectivity of Schmidt glycosidation (see Table 3, entries 1–4 for the formation of 74). …

The crystal structure of human CD1d with and without α-galactosylceramide

…, G Ritter, AR Fersht, GS Besra, RR Schmidt… - Nature …, 2005 - nature.com
The glycolipid α-galactosylceramide binds with high affinity to CD1d and stimulates natural
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α-…

Synthetic routes to thiooligosaccharides and thioglycopeptides

K Pachamuthu, RR Schmidt - Chemical reviews, 2006 - ACS Publications
The ongoing ability of bacteria to resist current antibiotic treatments highlights the need for
alternative strategies for inhibiting their pathogenicity. For many pathogens, including bacteria…

Hetero-Diels-Alder reaction in highly functionalized natural product synthesis

RR Schmidt - Accounts of Chemical Research, 1986 - ACS Publications
Functionally substituted dihydro-and tetrahydrofuran and-pyran structures play an important
role as intermediates in syntheses of highly functionalized natural products. They are not …

[HTML][HTML] Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy

…, M Salio, B Mathew, RR Schmidt… - The Journal of …, 2004 - Am Soc Clin Investig
Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration
of the glycolipid ligand α-galactosylceramide (α-GalCer) or the sphingosine-truncated α-…

[PDF][PDF] Facile synthesis of a-and P-0-Glycosyl imidates preparation of glycosides and disaccharides

RR Schmidt, J Michel - Angew. Chem. Inr. Ed. Engl, 1980 - thevespiary.org
Glycosides and saccharides are largely synthesized via haloses and their activation by
heavy metal salts-especially silver saltsI'-21. The disadvantages of this method are self-evident. …

[HTML][HTML] Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

…, Y Yang, AL Cogen, ZR Wu, LV Hooper, RR Schmidt… - Nature medicine, 2009 - nature.com
The normal microflora of the skin includes staphylococcal species that will induce inflammation
when present below the dermis but are tolerated on the epidermal surface without …

Glycosylation with highly reactive glycosyl donors: efficiency of the inverse procedure

RR Schmidt, A Toepfer - Tetrahedron letters, 1991 - Elsevier
α-Fucosylation with the reactive trichloroacetimidate 1 as donor and disaccharides 2 and 4
as acceptors led to a remarkable increase in yield under “inverse conditions”, ie addition of …