Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies
when deregulated by genomic or epigenomic events. Here, we describe a model "…

The hormone-dependent human breast cancer cell line MCF-7 secretes transforming growth
factor-8 (TGF-p), which can be detected in the culture medium in a biologically active form. …

Lack of estrogen receptor (ER) and presence of vimentin (VIM) associate with poor prognosis
in human breast cancer. We have explored the relationships between ER, VIM, and …

The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and
membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all of the …

Ever since Bishop and his co-workers discovered the c-myc gene in the late 1970s (Bishop
1982), voluminous literature has documented its central role in proliferation and malignant …

Matriptase is an epithelial-derived, integral membrane serine protease. The enzyme was
initially isolated from human breast cancer cells and has been implicated in breast cancer …

… transcription factor E2F-1 bind the Rb-1 gene product. The function of Rb-1 appears to
restrict cellular entry into the S phase of the cell cycle. It is thought that Rb binds E2F-1 to form a …

Data from basic research suggests that amplification of the proto-oncogene c-myc is important
in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance …

… Knabbe CK, Lippman ME, Greene GL, Dickson RB 1986 Phorbol ester induced phosphorylation
… Hanover JA, Dickson RB 1985 The possible link between receptor phosphorylation and …

We report that human breast cancer cells secrete a growth factor that is biologically and
immunologically similar to platelet-derived growth factor (PDGF). Serum-free medium …