User profiles for R. J. Hargreaves

Robert Hargreaves

Center for Astrophysics | Harvard & Smithsonian
Verified email at cfa.harvard.edu
Cited by 1940

Neurogenic inflammation in the context of migraine

DJ Williamson, RJ Hargreaves - Microscopy research and …, 2001 - Wiley Online Library
… Crawford JS, Konkol RJ. 1997. Familial hemiplegic migraine with crossed cerebellar …
Shepheard SL, Williamson DJ, Hill RG, Hargreaves RJ. 1993. The non-peptide neurokinin1 …

Pathophysiology of migraine—new insights

RJ Hargreaves, SL Shepheard - Canadian journal of neurological …, 1999 - cambridge.org
Current theories propose that the primary dysfunction in migraine occurs within the CNS
and that this evokes changes in blood vessels within pain-producing intracranial meningeal …

The role of molecular imaging in drug discovery and development

RJ Hargreaves - Clinical Pharmacology & Therapeutics, 2008 - Wiley Online Library
Molecular imaging biomarkers are playing an increasingly important role in efforts to increase
the probability of success of drug candidates by helping to validate novel drug targets in …

Distinct mechanism for antidepressant activity by blockade of central substance P receptors

…, L Hewson, D Smith, EJ Carlson, RJ Hargreaves… - Science, 1998 - science.org
The localization of substance P in brain regions that coordinate stress responses and receive
convergent monoaminergic innervation suggested that substance P antagonists might …

[HTML][HTML] The HITRAN2020 molecular spectroscopic database

IE Gordon, LS Rothman, RJ Hargreaves… - Journal of quantitative …, 2022 - Elsevier
The HITRAN database is a compilation of molecular spectroscopic parameters. It was
established in the early 1970s and is used by various computer codes to predict and simulate the …

[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

…, TM Fong, RJ Hargreaves - Proceedings of the …, 2007 - National Acad Sciences
[ 18 F]MK-9470 is a selective, high-affinity, inverse agonist (human IC 50 , 0.7 nM) for the
cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. …

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

…, J Metzger, DE MacIntyre, RG Hill, RJ Hargreaves - …, 1996 - Elsevier
These studies have compared the pharmacological profile of two non-peptide human type
neurokinin 1 (hNK 1 ) receptor selective antagonists, L-741,671 and a quaternised compound …

[PDF][PDF] The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake

…, J Blundell, GA Herman, HD Burns, RJ Hargreaves… - Cell Metabolism, 2008 - cell.com
Cannabinoid 1 receptor (CB1R) inverse agonists are emerging as a potential obesity therapy.
However, the physiological mechanisms by which these agents modulate human energy …

Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene‐related peptide on dural vessel diameter in the anaesthetized rat

DJ Williamson, RJ Hargreaves, RG Hill… - …, 1997 - Wiley Online Library
This study describes a novel intravital microscope technique for direct measurement of
dural blood vessel diameter through a closed cranial window in anaesthetized rats. This …

Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant

M Bergström, RJ Hargreaves, HD Burns… - Biological …, 2004 - Elsevier
BACKGROUND: Aprepitant is a highly selective substance P (neurokinin 1 [NK 1 ] receptor)
antagonist that significantly improves the pharmacotherapy of acute and delayed highly …