[HTML][HTML] Non-interferometric photoacoustic remote sensing microscopy

…, W Shi, K Bell, RJ Paproski, RJ Zemp - Light: Science & …, 2017 - nature.com
Elasto-optical refractive index modulation due to photoacoustic initial pressure transients
produced significant reflection of a probe beam when the absorbing interface had an …

Porphyrin nanodroplets: Sub‐micrometer ultrasound and photoacoustic contrast imaging agents

RJ Paproski, A Forbrich, E Huynh, J Chen, JD Lewis… - Small, 2016 - Wiley Online Library
A novel class of all‐organic nanoscale porphyrin nanodroplet agents is presented which is
suitable for multimodality ultrasound and photoacoustic molecular imaging. Previous …

[HTML][HTML] Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors

RJ Paproski, A Heinmiller, K Wachowicz, RJ Zemp - Scientific reports, 2014 - nature.com
Photoacoustic imaging is an emerging hybrid imaging technology capable of breaking
through resolution limits of pure optical imaging technologies imposed by optical-scattering to …

Tyrosinase as a dual reporter gene for both photoacoustic and magnetic resonance imaging

RJ Paproski, AE Forbrich, K Wachowicz… - Biomedical optics …, 2011 - opg.optica.org
Reporter genes are useful scientific tools for analyzing promoter activity, transfection
efficiency, and cell migration. The current study has validated the use of tyrosinase (involved in …

Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment

W Shi, RJ Paproski, R Moore… - Journal of Biomedical …, 2014 - spiedigitallibrary.org
While more than 90% of cancer deaths are due to metastases, our ability to detect circulating
tumor cells (CTCs) is limited by low numbers of these cells in the blood and factors …

The role of human nucleoside transporters in uptake of 3′-deoxy-3′-fluorothymidine

RJ Paproski, AML Ng, SYM Yao, K Graham… - Molecular …, 2008 - ASPET
3′-Deoxy-3′-fluorothymidine (FLT) is a positron emission tomography (PET) tracer used
to identify proliferating tumor cells. The purpose of this study was to characterize FLT …

[HTML][HTML] Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases …

RJ Paproski, SYM Yao, N Favis, D Evans, JD Young… - PloS one, 2013 - journals.plos.org
Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters
to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of …

Biodistribution and uptake of 3′-deoxy-3′-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model

RJ Paproski, M Wuest, HS Jans… - Journal of Nuclear …, 2010 - Soc Nuclear Med
18 F-3′-Deoxy-3′-fluorothymidine ( 18 F-FLT) is a PET tracer that accumulates in
proliferating tissues. The current study was undertaken to determine whether equilibrative …

Enhanced detection of cancer biomarkers in blood-borne extracellular vesicles using nanodroplets and focused ultrasound

RJ Paproski, J Jovel, GKS Wong, JD Lewis, RJ Zemp - Cancer Research, 2017 - AACR
The feasibility of personalized medicine approaches will be greatly improved by the
development of noninvasive methods to interrogate tumor biology. Extracellular vesicles shed by …

[HTML][HTML] Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

K Stoletov, L Willetts, RJ Paproski, DJ Bond… - Nature …, 2018 - nature.com
Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target
its key rate-limiting steps. We have previously shown that the entry of cancer cells into the …