Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

…, DB Carter, AG Tomasselli, LA Parodi, RL Heinrikson… - Nature, 1999 - nature.com
Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant
Alzheimer's disease 1 , 2 , 3 . Cleavage of APP by unidentified proteases, referred to as …

Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate

RL Heinrikson, SC Meredith - Analytical biochemistry, 1984 - Elsevier
Methods for the quantitative derivatization of amino acids with phenylisothiocyanate and for
the separation and quantitation of the resulting phenylthiocarbamyl derivatives by reverse-…

Targeting the HIV-protease in AIDS therapy: a current clinical perspective

AG Tomasselli, RL Heinrikson - … et Biophysica Acta (BBA)-Protein Structure …, 2000 - Elsevier
This review deals with clinical applications of compounds that inhibit the action of the protease
encoded within the genome of human immunodeficiency virus (HIV). The HIV-protease is …

Human β-secretase (BACE) and BACE inhibitors

…, MJ Bienkowski, S Sinha, RL Heinrikson - Journal of medicinal …, 2003 - ACS Publications
Introduction β-Secretase (BACE) is a proteolytic enzyme involved in the processing of an
integral membrane protein known as amyloid precursor protein, or APP. The proteolysis of APP …

[HTML][HTML] Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

…, IM Reardon, HA Zürcher-Neely, RL Heinrikson… - Journal of Biological …, 1993 - Elsevier
The structure of beta-amyloid (beta A) from Alzheimer disease brains was examined to
determine if post-translational modifications might be linked to the abnormal deposition of this …

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

…, HA Zurcher-Neely, IM Reardon, RL Heinrikson… - Nature, 1990 - nature.com
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist
protein (IRAP) which was purified and partially sequenced. A complementary DNA coding …

Platelet factor 4 is chemotactic for neutrophils and monocytes.

…, D Chang, GL Griffin, RL Heinrikson… - Proceedings of the …, 1981 - National Acad Sciences
Platelet factor 4 is shown to be a chemotactic protein for human polymorphonuclear leukocytes
and monocytes at concentrations found in human serum and reached locally in injured …

Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural …

RL Heinrikson, ET Krueger, PS Keim - Journal of Biological Chemistry, 1977 - Elsevier
The complete amino acid sequence of Crotalus adamanteus venom phospholipase A2-alpha
has been determined by analysis of the five tryptic peptides from the citraconylated, …

Amino acid sequence of human platelet factor 4.

…, M Farmer, RL Heinrikson - Proceedings of the …, 1977 - National Acad Sciences
Human platelet factor 4, a protein that binds heparin, has been purified to apparent homogeneity
and the complete amino acid sequence of the protein has been determined. The 70-…

A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation

…, V Karacostas, B Moss, TK Sawyer, RL Heinrikson… - Science, 1990 - science.org
A synthetic peptidemimetic substrate of the human immunodeficiency virus 1 (HIV-1)
protease with a nonhydrolyzable pseudodipeptidyl insert at the protease cleavage site was …