Cytochalasin B inhibits glucose transport in human erythrocytes by competing with glucose
for the carrier on the inner surface of the cell membrane, but there is no cytochalasin site …

The sidedness of phloretin binding to the glucose carrier has been determined by comparing
the type of inhibition produced in zerotrans entry and zerotrans exit experiments. Initial …

General rate equations are developed for the case in which an inhibitor may combine with
the freeenzyme, the enzyme-substrate complex, and with a subsequently formed enzyme-…

The relationships between structure, affinity and transport activity in the choline transport
system of erythrocytes have been investigated in order to (i) explore the nature of the carrier site …

The principle of microscopic reversibility was formulated for elementary reactions at equilibrium.
It follows from the principle that for any system at equilibrium, and for any elementary …

Numerous mechanisms have been suggested to explain transport across biological membranes,
all of which fall into one or the other of two distinct categories. In some, substrate sites …

Materials and Methods Human blood was obtained from an outdated blood bank supply. All
chemicals were of commercial reagent grade. Rates of sugar transport were measured by …

… A preliminary report of part of this work has already appeared (Krupka, 1965b). … bound at
the anionic site without greatly hindering deacetylation (Krupka, 1965a). If the ionizing group …

RM Krupka abstract: Evidence is presented to show that the same active center in a purified
preparation of bovine erythro-cyte acetylcholinesterase acts upon cationic and un-charged …

The analysis of transport kinetics has lacked both a unified treatment in which general rate
equations are written entirely in terms of experimental parameters, and a convention by which …