An ethanol extract of Psoralea corylifolia caused strong DNA polymerase inhibition in a
whole cell bioassay specific for inhibitors of DNA replication enzymes. Bioassay-directed …

XK469 (NSC 697887) is a synthetic quinoxaline phenoxypropionic acid derivative that possesses
unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. We …

… Permana PA, Ferrer CA and Snapka RM, Inverse relationship … Shin CG, Strayer JM, Wani
MA and Snapka RM, Rapid evaluation … Snapka RM and Yamasaki EF, Topoisomerase …

Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193),
are widely believed to be only catalytic inhibitors of topoisomerase II. However, …

The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking
features normally associated with DNA binding by intercalation or minor groove binding. …

Chloroquinoxaline sulfonamide (chlorosulfaquinoxaline, CQS, NSC 339004)is active
against murine and human solid tumors. On the basis of its structural similarity to the …

Octahedral ruthenium complexes, capable of photodynamic singlet oxygen production at
near 100% efficiency, were shown to cause light-dependent covalent crosslinking of p53 and …

The two known antineoplastic quinoxaline topoisomerase II poisons, XK469 (NSC 697887)
and CQS (chloroquinoxaline sulfonamide, NSC 339004), were compared for DNA cleavage …

Previous work has shown that mammalian cells that carry unstably amplified genes for
dihydrofolate reductase (DHFR) gradually lose the amplified DHFR genes when grown in the …

… of SV40 DNA replication intermediates were performed as described (Snapka et al., … ,
the A- and B-family dimer ladders overlap at the highest catenation levels (Snapka et al., …