The metabolite glutathione fulfills many important and chemically complex roles in protecting
cellular components from the deleterious effects of toxic species. GSH combines with …

… 41"54'82l The failure to direct expression of reporter transgenes harboring up to 5.5kb of
the GCSh promoter (JJ Gipp, AC Wild and RT Mulcahy, unpublished observation) leads us to …

A role for DTD in the bioreductive activation of mitomycin C was supported by indirect
evidence utilizing enzyme inhibitors in cellular systems. Using a cell-free system, we have …

Exposure of HepG2 cells to β-naphthoflavone (β-NF) or pyrrolidine dithiocarbamate (PDTC)
resulted in the up-regulation of the γ-glutamylcysteine synthetase catalytic (GCS h ) and …

Glutathione (GSH) is an abundant cellular non-protein sulfhydryl that functions as an
important protectant against reactive oxygen species and electrophiles, is involved in the …

Transactivation of phase II detoxification enzymes and antioxidant proteins is mediated by the
Cap'N′Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the actin-…

The rate-limiting step in the de novo synthesis of the cellular protectant glutathione is
catalyzed by γ-glutamylcysteine synthetase (GCS; also known as glutamine-L-cysteine ligase, …

Pyrrolidine dithiocarbamate (PDTC) induction of the human glutamate cysteine ligase
modulatory (GCLM) gene is dependent on activation of the mitogen-activated protein kinases (…

Genes encoding the catalytic (GCS h ) and regulatory (GCS l ) subunits of human γ-glutamylcysteine
synthetase (γGCS), which catalyzes the rate limiting step in glutathione synthesis, …

Purpose: A phase I dose-escalation trial of intrave-nous (IV) L-buthionine-SR-sulfoximine
(BSO) with melphalan (L-PAM) was performed to determine the toxicity and biologic activity …