User profiles for R. W. Doms
 | Robert W. DomsChildren's Hospital of Philadelphia Verified email at chop.edu Cited by 53067 |
HIV: cell binding and entry
The first step of the human immunodeficiency virus (HIV) replication cycle—binding and entry
into the host cell—plays a major role in determining viral tropism and the ability of HIV to …
into the host cell—plays a major role in determining viral tropism and the ability of HIV to …
Human immunodeficiency virus type 2
JD Reeves, RW Doms - Journal of general virology, 2002 - microbiologyresearch.org
The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV). …
than 34 million individuals currently infected with human immunodeficiency virus (HIV). …
The plasma membrane as a combat zone in the HIV battlefield
In the life of a cell, the plasma membrane fulfills a range of functions that go far beyond the
shaping and maintenance of architectural features and the absorption of nutrients. The …
shaping and maintenance of architectural features and the absorption of nutrients. The …
Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.
RW Doms, G Russ, JW Yewdell - The Journal of cell biology, 1989 - rupress.org
Brefeldin A (BFA) has been reported to block protein transport from the ER and cause
disassembly of the Golgi complex. We have examined the effects of BFA on the transport and …
disassembly of the Golgi complex. We have examined the effects of BFA on the transport and …
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
…, S Rana, Y Yi, RJ Smyth, RG Collman, RW Doms… - Nature, 1996 - nature.com
HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …
[HTML][HTML] A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
Here, we show that the β-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV
viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells …
viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells …
[HTML][HTML] A new classification for HIV-1
The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro, but
these phenotypes can change in vivo with profound implications for viral transmission, …
these phenotypes can change in vivo with profound implications for viral transmission, …
HIV vaccine design and the neutralizing antibody problem
DR Burton, RC Desrosiers, RW Doms, WC Koff… - Nature …, 2004 - nature.com
Eliciting broadly neutralizing antibodies to human immunodeficiency virus could bring
closer the goal of a successful AIDS vaccine. Here the International AIDS Vaccine Initiative …
closer the goal of a successful AIDS vaccine. Here the International AIDS Vaccine Initiative …
[HTML][HTML] CD4-independent infection by HIV-2 is mediated by fusin/CXCR4
Several members of the chemokine receptor family have been shown to function in association
with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these …
with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these …
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
…, D Weissman, RW Doms - Proceedings of the …, 1999 - National Acad Sciences
CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains, respectively,
and a threshold number of CD4 and chemokine receptor molecules is required to support …
and a threshold number of CD4 and chemokine receptor molecules is required to support …