Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit
the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-…

… values for formation of carbonium ions from the respective diol epoxides (using the model
previously discussed) differ greatly, with the 3,4-diol-l,2-epoxide ("bay region" epoxide) being …

Evidence supporting the conclusion that 7,8‐dihydroxy‐9,10‐epoxy‐7,8,9,10‐tetra‐hydrobenzo[a]pyrenes
are ultimate mutagenic and carcinogenic forms of benzo[a]‐pyrene (BP) is …

The hydrolysis rates, mutagenicities and tumorigenicities of a variety of diol epoxides and
tetrahydroepoxides derived from polycyclic aromatic hydrocarbons (PAH) are examined. Bay-…

The polycyclic aromatic hydrocarbons (PAH’s)* represent a particularly intriguing class of
carcinogens, because their structural similarity as well as their * Abbreviations: PAH, polycyclic …

Three diastereomeric pairs of diol epoxides, two tetrahydro-epoxides, and the K-region oxide
of the polycyclic aromatic hydrocarbon benz[a]anthracene were evaluated for mutagenic …

Benzo[a]anthracena and the 5 metabolically possible trans dihydrodiols of benzo[a]anthracene
were metabolized, in the presence of S.thyphimurium strain TA100, by a highly purified …

… Additional support for bay region activation of benz[a]anthracene comes from a re-examination
ofdata on the carcinogenicity of several benz[ajanthracene derivatives. The available …

… ides of certain hydrocarbons backingbay regions could have reactivity equal to or greater
than bay-region diob-epoxides derived from some carcinogenic hydrocarbons with bay re …

Benzo(a)anthracene (BA) and several benzo-ring derivatives of BA were tested for their
tumor-initiating activity on mouse skin. A single topical application of 0.1 to 2.0 µmol of …