[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

…, KS Ferreira, V Fonsato, J Fraczek, R Gebhardt… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Metabolic zonation of the liver: regulation and implications for liver function

R Gebhardt - Pharmacology & therapeutics, 1992 - Elsevier
Liver parenchyma shows a remarkable heterogeneity of the hepatocytes along the porto-central
axis with respect to ultrastructure and enzyme activities resulting in different cellular …

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard …

R Gebhardt, JG Hengstler, D Müller… - Drug metabolism …, 2003 - Taylor & Francis
Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration. …

Glycogen in astrocytes: possible function as lactate supply for neighboring cells

R Dringen, R Gebhardt, B Hamprecht - Brain research, 1993 - Elsevier
In order to contribute to the elucidation of the function of astrocyte glycogen in brain, studies
on the fate of the glucosyl residues of glycogen were carried out on astroglia-rich primary …

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.

R Gebhardt, D Mecke - The EMBO journal, 1983 - embopress.org
… and growth hormone were those described by Gebhardt and Mecke (1979a). … or to the
hormonal stimulation of the cells in culture (Gebhardt and Mecke, 1979a). Although quantitative …

Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat …

R Gebhardt - Toxicology and applied pharmacology, 1997 - Elsevier
Primary rat hepatocyte cultures exposed totert-butylhydroperoxide (t-BHP) or cumene
hydroperoxide were used to assess the antioxidative and protective potential of water-soluble …

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

…, M Hermes, V Puppe, R Gebhardt… - Proceedings of the …, 2010 - National Acad Sciences
Only little is known about how cells coordinately behave to establish functional tissue structure
and restore microarchitecture during regeneration. Research in this field is hampered by …

Hepatocyte-specific Smad7 expression attenuates TGF-β–mediated fibrogenesis and protects against liver damage

…, I Ilkavets, S Ehnert, E Ueberham, R Gebhardt… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: The profibrogenic role of transforming growth factor (TGF)-β in liver
has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. …

[HTML][HTML] Tubular overexpression of transforming growth factor-β1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

…, M LeHir, N Picard, F Theilig, R Gebhardt… - The American journal of …, 2010 - Elsevier
We recently showed in a tetracycline-controlled transgenic mouse model that overexpression
of transforming growth factor (TGF)-β1 in renal tubules induces widespread peritubular …

Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts

R Gebhardt - Journal of Pharmacology and Experimental …, 1998 - ASPET
… /ml of the artichoke extracts (Gebhardt R, unpublished results). Thus, … could be excluded
(Gebhardt R, unpublished results). … by the artichoke extracts (Gebhardt R, unpublished results). …