… very high amphetamine doses, and repeated exposure to lower doses equivalent to the
human therapeutic range do not produce toxicity in rodents (for example, Segal and Kuczenski …

Tardive dyskinesia has been and continues to be a significant problem associated with long-term
antipsychotic use, but its pathophysiology remains unclear. In the last 10 years, …

… , can occur during the course of exposure to stimulants (Kuczenski and Segal, 1999a,b,c).
Consideration … Segal DS, Kuczenski R. 1997a. Repeated binge exposure to amphetamine and …

… Segal DS and Kuczenski R. (1987) Individual differences in responsiveness to single
and repeated amphetamine administration: behavioral characteristics and neurochemical …

Microdialysis in behaving animals was used to concomitantly characterize the dopamine
and 5-HT responses in the caudate and the norepinephrine response in the hippocampus to …

… one feature of the AMPH response, ie, response perseveration, does become progressively
more pronounced with increasing dose, and our data show that there is a high correlation (R …

Methylphenidate (MP) (ritalin) is widely used in the treatment of children and adolescents with
attention deficit hyperactivity disorder, but little is known about therapeutic mechanisms or …

… Furthermore, we have recently observed (Kuczenski and Segal, unpublished observations)
that baseline dialysate concentrations of 3-methoxytyramine occur at about 50% of DA …

Given the mounting convergent evidence implicating many more genes in complex disorders
such as bipolar disorder than the small number identified unambiguously by the first‐…

The prescribed use of methylphenidate (Ritalin) in the treatment of attention deficit
hyperactivity disorder has risen dramatically in recent years. The relative roles of dopamine, …