I had the good fortune of coming to the McArdle Laboratory for Cancer Research in 1952 as
a graduate student of James and Elizabeth Miller.* The Millers tried very hard to instill their …

Growth is a fundamental process of life. Growth requirements are well‐characterized
experimentally for many microbes; however, we lack a unified model for cellular growth. Such a …

… RL Chang led the network reconstruction and computational modeling; L Ghamsari led the
… RL Chang led the network reconstruction and computational modeling; L Ghamsari led the …

The effects of several naturally occurring and synthetic flavonoids on the metabolism of
benzo(a)pyrene and aflatoxin B 1 were evaluated. Addition of apigenin, chrysin, fisetin, flavanone…

Enzymes are thought to have evolved highly specific catalytic activities from promiscuous
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …

Topical application of curcumin inhibits chemically induced carcinogenesis on mouse skin,
and oral administration of curcumin inhibits chemically induced oral, forestomach, duodenal, …

Commercial grade curcumin (∼77% curcumin, 17% demethoxycurcumin and 3%
bisdemethoxycurcumin) is widely used as a yellow coloring agent and spice in foods. In the present …

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets
based on their ligand binding sites. Concurrent developments in systems biology …

Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit
the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-…

Studies by several investigators have shown that 12–0-tetradecanoylphorbol-13-acetate (TPA)
is an extraordinarily potent stimulator of differentiation of cultured human promyelocytic …