The 2-phenylaminopyrimidine derivative STI571 has been shown to selectively inhibit the
tyrosine kinase domain of the oncogenicbcr/abl fusion protein. The activity of this inhibitor has …

Betulinic acid is a triterpene with selective cytotoxicity against melanoma, neuroectodermal
and malignant brain tumor cell lines. In this study the betulinic acid activity was evaluated, in …

Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment
of human tumors. Resistance to doxorubicin is described as a multifactorial phenomenon …

… The 8(R)-fluoro epimer was more effective when compared with the 8(S)-epimer and with …
The compound 8(R)-fluoro idarubicin was also very effective, almost as effective as …

Limited information is available concerning the expression and role of microRNAs in
prostate cancer. In this study, we investigated the involvement of miR-205 in prostate …

Stable transfection of human ovarian carcinoma cells with survivin cDNA caused a four- to
sixfold increase in cell resistance to taxotere and taxol (two-sided Student's t test, p <0.05), …

p53 status may be a determinant of chemosensitivity of tumor cells; however, its involvement
in cellular resistance to cisplatin remains uncertain. To investigate the relationships …

… Spearman's correlation coefficient (r S ) with associated P value was calculated for PTEN
mRNA and miR-21 expression in clinical samples. Two-tailed P values < 0.05 were considered …

Multinuclear platinum complexes represent a new class of anticancer agents, distinct in
terms of DNA binding features and the profile of antitumor activity from their mononuclear …

The MTT calorimetric assay determines the ability of viable cells to convert a soluble
tetrazolium salt [3–(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) into an …