Prostaglandins E 2 and F 2α regulate a number of physiological functions in reproductive
tissues, and concentrations of these bioactive modulators increase during pregnancy. …

The solubilization, separation, and purification of microsomal NADPH-cytochrome c reductase
and cytochrome P-450 by Lu and Coon (1968) upon treatment ofmicrosomes with sodium …

NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase catalyzes the oxidation of many
prostaglandins at C-15, resulting in a subsequent reduction in their biological activity. We …

The time course of metabolism of benzo(a)pyrene by liver microsomes from rats given injections
of corn oil, phenobarbital, or 3-methylcholanthrene was followed by high-pressure liquid …

Cytochrome P-450-dependent prostaglandin omega-hydroxylation is induced over 100-fold
during late gestation in rabbit pulmonary microsomes (Powell, WS (1978) J. Biol. Chem. 253…

Spectrophotometric changes in the extent of NADPH, but not NADH, reduction of microsomal
cytochrome b 5 are correlated with the utilization of oxygen and the accumulation of lipid …

… The NAD+dependent PGDH was purified from the lungs of pregnant rabbits by a modification
of the procedure of Bergholte and Okita (30). The modification was the substitution of a …

… purified by the procedures described by Okita and Okita (16) and … Okita ef al. (20) for
arachidonate and PGE1. The LTB, products were examined as described by Soberman and Okita (…

… min, 400 cpm) was prepared by incubationof (l-14C]lauric acid with liver microsomes prepared
from rats treated with bis(2-ethylhexyl) phthalate to induce a;-hydroxylase activity (Okita & …

The in vivo formation of w-oxidized metabolites of prostaglandins has been suggested to be
mediated by the cytochrome P-450 monooxygenase system. We have isolated a …