Molecular identification of the Ca 2+ -dependent chloride channel TMEM16A (ANO1)
provided a fundamental step in understanding Ca 2+ -dependent Cl − secretion in epithelia. …

Purinergic P2X 7 receptors (P2X 7 R) are fundamental to innate immune response. In
macrophages, transient stimulation of P2X 7 R activates several transport mechanisms and …

TMEM16A (anoctamin 1, Ano1), a member of a family of 10 homologous proteins, has been
shown to form an essential component of Ca 2+ ‐activated CU channels. TMEM16A‐null …

Purpose: Voltage-gated Kv potassium channels, like ether a go-go (EAG) channels, have
been recognized for their oncogenic potential in breast cancer and other malignant tumors. …

The calcium-activated chloride channel anoctamin1 (ANO1; TMEM16A) is fundamental for
the function of epithelial organs. Mice lacking ANO1 expression exhibit transport defects and …

Frequent gene amplification of the receptor-activated calcium-dependent chloride channel
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …

Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl − channels
transiently activated by an increase in intracellular Ca 2+ . These channels are essential for …

All vertebrate cells regulate their cell volume by activating chloride channels of unknown
molecular identity, thereby activating regulatory volume decrease. We show that the Ca 2+ -…

Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis
and is associated with poor survival. Ano1 (Dog1) is an established and sensitive marker for …

Outwardly rectifying chloride channels (ORCC, ICOR) of intermediate single-channel conductance
of around 50 pS, are ubiquitously expressed, but have remained a mystery since their …