Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Cholinesterase inhibitors, the current frontline symptomatic treatment for Alzheimer’s disease
(AD), are associated with low efficacy and adverse effects. M1 muscarinic acetylcholine …
(AD), are associated with low efficacy and adverse effects. M1 muscarinic acetylcholine …
G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists
RL Thomas, R Mistry, CJ Langmead, MD Wood… - … of Pharmacology and …, 2008 - ASPET
The M 1 muscarinic acetylcholine (mACh) receptor is among a growing number of G protein-coupled
receptors that are able to activate multiple signaling cascades. AC-42 (4-n-butyl-1-[…
receptors that are able to activate multiple signaling cascades. AC-42 (4-n-butyl-1-[…
Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy
RM Cooke, R Mistry, RAJ Challiss… - Journal of …, 2013 - Soc Neuroscience
Nitric oxide (NO) is an important signaling molecule with a variety of functions in the CNS,
including a potential role in modulating neuronal growth and synapse formation. In the present …
including a potential role in modulating neuronal growth and synapse formation. In the present …
Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle
JM Willets, PJ Brighton, R Mistry… - Molecular …, 2009 - academic.oup.com
Oxytocin plays an important role in the progression, timing, and modulation of uterine
contraction during labor and is widely used as an uterotonic agent. We investigated the …
contraction during labor and is widely used as an uterotonic agent. We investigated the …
Evidence for cross‐talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal‐regulated kinase …
DC Hornigold, R Mistry, PD Raymond… - British journal of …, 2003 - Wiley Online Library
We have examined possible mechanisms of cross‐talk between the G q/11 ‐linked M 3
muscarinic acetylcholine (mACh) receptor and the G i/o ‐linked M 2 mACh receptor by stable …
muscarinic acetylcholine (mACh) receptor and the G i/o ‐linked M 2 mACh receptor by stable …
[HTML][HTML] Structural aspects of M3 muscarinic acetylcholine receptor dimer formation and activation
…, Y Zhou, T Liu, Y Wang, SM McMillin, R Mistry… - The FASEB …, 2012 - ncbi.nlm.nih.gov
To explore the structural mechanisms underlying the assembly and activation of family A GPCR
dimers, we used the rat M 3 muscarinic acetylcholine receptor (M3R) as a model system. …
dimers, we used the rat M 3 muscarinic acetylcholine receptor (M3R) as a model system. …
[HTML][HTML] Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation
J Hu, K Hu, T Liu, MK Stern, R Mistry… - Journal of Biological …, 2013 - ASBMB
Class AG protein-coupled receptors (GPCRs) are able to form homodimers and/or oligomeric
arrays. We recently proposed, based on bioluminescence resonance energy transfer …
arrays. We recently proposed, based on bioluminescence resonance energy transfer …
An investigation of whether agonist‐selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs …
R Mistry, MR Dowling… - British journal of …, 2005 - Wiley Online Library
1 A range of muscarinic acetylcholine (mACh) receptor agonists (methacholine (MCh),
oxotremorine‐M (OXO‐M), oxotremorine (OXO), arecoline (AREC), bethanechol (BETH), …
oxotremorine‐M (OXO‐M), oxotremorine (OXO), arecoline (AREC), bethanechol (BETH), …
Differential regulation of β2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle
CA Nash, CP Nelson, R Mistry, C Moeller-Olsen… - Cellular …, 2018 - Elsevier
Generation of cAMP through G s -coupled G protein-coupled receptor (GPCR) [eg β 2 -adrenoceptor
(β 2 AR), adenosine A 2B receptor (A 2B R)] activation, induces arterial smooth …
(β 2 AR), adenosine A 2B receptor (A 2B R)] activation, induces arterial smooth …
[HTML][HTML] FRET-Based Detection of M1 Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists
D Markovic, J Holdich, S Al-Sabah, R Mistry, C Krasel… - PloS one, 2012 - journals.plos.org
Background and Objective Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane,
G protein-coupled receptors that regulate a variety of physiological processes and …
G protein-coupled receptors that regulate a variety of physiological processes and …