User profiles for Ralph R. Weichselbaum
ralph weichselbaumprofessor radiation oncology university of chicago Verified email at radonc.uchicago.edu Cited by 111284 |
Head and neck cancer
EE Vokes, RR Weichselbaum… - New England Journal …, 1993 - Mass Medical Soc
Head and neck cancer was last reviewed in the Journal in 1983 1 . At that time, there was
promising new information on a possible role for chemotherapy 1 , 2 . During the past decade, …
promising new information on a possible role for chemotherapy 1 , 2 . During the past decade, …
[HTML][HTML] Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice
…, M Beckett, T Darga, RR Weichselbaum… - The Journal of …, 2014 - Am Soc Clin Investig
High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific
immunity, which enhances tumor control both locally and distantly. Unfortunately, local …
immunity, which enhances tumor control both locally and distantly. Unfortunately, local …
Accurate three-dimensional registration of CT, PET, and/or MR images of the brain
…, DR Spelbring, RR Weichselbaum… - Journal of computer …, 1989 - journals.lww.com
A surface matching technique has been developed to register multiple imaging scans of the
brain in three dimensions, with accuracy on the order of the image pixel sizes. Anatomic …
brain in three dimensions, with accuracy on the order of the image pixel sizes. Anatomic …
[PDF][PDF] STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
Ionizing radiation-mediated tumor regression depends on type I interferon (IFN) and the
adaptive immune response, but several pathways control I IFN induction. Here, we demonstrate …
adaptive immune response, but several pathways control I IFN induction. Here, we demonstrate …
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
…, R Chin, T Tu, RR Weichselbaum… - Blood, The Journal …, 2009 - ashpublications.org
Patients with locally advanced cancer or distant metastasis frequently receive prolonged
treatment with chemotherapy and/or fractionated radiotherapy (RT). Despite the initial clinical …
treatment with chemotherapy and/or fractionated radiotherapy (RT). Despite the initial clinical …
Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
…, A Koons, DM Hari, DW Kufe, RR Weichselbaum - Cancer research, 1999 - AACR
The family of vascular endothelial growth factor (VEGF) proteins include potent and specific
mitogens for vascular endothelial cells that function in the regulation of angiogenesis. …
mitogens for vascular endothelial cells that function in the regulation of angiogenesis. …
Oligometastases revisited
RR Weichselbaum, S Hellman - Nature reviews Clinical oncology, 2011 - nature.com
We previously proposed a clinical state of metastasis termed 'oligometastases' that refers to
restricted tumor metastatic capacity. The implication of this concept is that local cancer …
restricted tumor metastatic capacity. The implication of this concept is that local cancer …
Radiotherapy and immunotherapy: a beneficial liaison?
Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …
Combined effects of angiostatin and ionizing radiation in antitumour therapy
…, GA Soff, VP Sukhatme, DW Kufe, RR Weichselbaum - Nature, 1998 - nature.com
Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour
progression 1 , 2 , 3 , 4 , 5 . Angiostatin, a proteolytic fragment of plasminogen 6 that was …
progression 1 , 2 , 3 , 4 , 5 . Angiostatin, a proteolytic fragment of plasminogen 6 that was …
The efficacy of radiotherapy relies upon induction of type I interferon–dependent innate and adaptive immunity
…, Y Lee, L Chlewicki, NN Khodarev, RR Weichselbaum… - Cancer research, 2011 - AACR
The most widely held explanation for the efficacy of local radiotherapy (RT) is based on
direct cytotoxicity to cancer cells through the induction of lethal DNA damage. Recent studies …
direct cytotoxicity to cancer cells through the induction of lethal DNA damage. Recent studies …