Cardiogenesis within embryos or associated with heart repair requires stem cell differentiation
into energetically competent, contracting cardiomyocytes. While it is widely accepted that …

Embryonic stem cells have the distinct potential for tissue regeneration, including cardiac
repair. Their propensity for multilineage differentiation carries, however, the liability of …

Decoding of the bioenergetic signature underlying embryonic stem cell cardiac differentiation
has revealed a mandatory transformation of the metabolic infrastructure with prominent …

Ventricular load can precipitate development of the heart failure syndrome, yet the molecular
components that control the cardiac adaptive response to imposed demand remain partly …

Background Age‐related heart diseases are significant contributors to increased morbidity
and mortality. Emerging evidence indicates that mitochondria within cardiomyocytes …

Genetically modified mice have advanced our understanding of valve development and
disease. Yet, human pathophysiological valvulogenesis remains poorly understood. Here we …

Pluripotent stem cells demonstrate an inherent propensity for unrestricted multi-lineage
differentiation. Translation into regenerative applications requires identification and isolation of …

The nuclear envelope (NE) is critical for numerous fundamental cellular functions, and mutations
in several NE constituents can lead to a heterogeneous spectrum of diseases. We used …

Background Energetic and metabolic circuits that orchestrate cell differentiation are largely
unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase (AMPK) …

Reprogramming strategies influence the differentiation capacity of derived induced
pluripotent stem (iPS) cells. Removal of the reprogramming factor c-Myc reduces tumorigenic …