Agonist properties of N, N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors

RL Smith, H Canton, RJ Barrett… - Pharmacology …, 1998 - Elsevier
… Author links open overlay panel Randy L. Smith a , Hervé Canton a , Robert J. Barrett a ,
Elaine Sanders-Bush a … RL SMITH, H. CANTON, RJ BARRETT AND E. SANDERS-BUSH. …

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral …

…, CK Jones, EJ Herman, AS Kane, RL Smith… - Molecular …, 2010 - ASPET
Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel
treatments for multiple central nervous system (CNS) disorders, including anxiety and …

Evolution of Populus nigra (sect. Aigeiros): introgressive hybridization and the chloroplast contribution of Populus alba (sect. Populus)

RL Smith, KJ Sytsma - American journal of botany, 1990 - Wiley Online Library
Restriction site variation in chloroplast DNA and nuclear ribosomal DNA was examined in
16 accessions from the Salicaceae comprising ten species of Populus and one outgroup …

A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis

MA Benneyworth, Z Xiang, RL Smith, EE Garcia… - Molecular …, 2007 - ASPET
Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu)
receptors have robust efficacy in treating positive and negative symptoms in patients with …

Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor.

RL Smith, RJ Barrett, E Sanders-Bush - Journal of Pharmacology and …, 1995 - ASPET
The purposes of this study were to determine: first, if animals could be trained to discriminate
a serotonin (5-HT)2 receptor agonist from a 5-HT2 receptor antagonist; second, which 5-…

[HTML][HTML] Behavioral tolerance to lysergic acid diethylamide is associated with reduced serotonin-2A receptor signaling in rat cortex

PJ Gresch, RL Smith, RJ Barrett… - …, 2005 - nature.com
Tolerance is defined as a decrease in responsiveness to a drug after repeated administration.
Tolerance to the behavioral effects of hallucinogens occurs in humans and animals. In this …

Role of Gq protein in behavioral effects of the hallucinogenic drug 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane

EE Garcia, RL Smith, E Sanders-Bush - Neuropharmacology, 2007 - Elsevier
Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including
schizophrenia. In addition, several studies indicate that G q -coupled 5-HT 2A receptors …

Positive porn: Educational, medical, and clinical uses

MA Watson, RD Smith - American Journal of Sexuality Education, 2012 - Taylor & Francis
Despite its widespread use, pornography has been vilified as a symptom of personal and
cultural depravity and as a cause of rape, aggression, devaluation of women, and marital …

Mechanism of tolerance development to 2, 5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor

RL Smith, RJ Barrett, E Sanders-Bush - Psychopharmacology, 1999 - Springer
Rationale: Defining the mechanism of tolerance development to hallucinogenic drugs will
help to explain their mechanism of action. Objectives: The present study was conducted to …

Discovery of Molecular Switches That Modulate Modes of Metabotropic Glutamate Receptor Subtype 5 (mGlu5) Pharmacology in Vitro and in Vivo within a Series of …

…, J Kedrowski, JM Rook, RL Smith… - Journal of medicinal …, 2009 - ACS Publications
We describe the synthesis and SAR of a series of analogues of the mGlu 5 partial antagonist
5-(phenylethynyl)pyrimidine. New molecular switches are identified that modulate the …