[HTML][HTML] High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells
R Mishra, SN Emancipator, T Kern, MS Simonson - Kidney international, 2005 - Elsevier
… Author links open overlay panel Rangnath Mishra , Steven N. Emancipator , Timothy Kern
, Michael S. … Mishra, P. Leahy, M. Simonson … Mishra, SN Emancipator, C. Miller, et al. …
, Michael S. … Mishra, P. Leahy, M. Simonson … Mishra, SN Emancipator, C. Miller, et al. …
[HTML][HTML] AMP-activated protein kinase inhibits transforming growth factor-β-induced Smad3-dependent transcription and myofibroblast transdifferentiation
R Mishra, BL Cool, KR Laderoute, M Foretz… - Journal of Biological …, 2008 - ASBMB
In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in
phenotype producing profibrotic effector cells that secrete and remodel the extracellular matrix. …
phenotype producing profibrotic effector cells that secrete and remodel the extracellular matrix. …
[HTML][HTML] Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability
J Fernandez, I Yaman, R Mishra, WC Merrick… - Journal of Biological …, 2001 - ASBMB
The cationic amino acid transporter, Cat-1, facilitates the uptake of the essential amino acids
arginine and lysine. Amino acid starvation causes accumulation and increased translation …
arginine and lysine. Amino acid starvation causes accumulation and increased translation …
Hyperglycemia-induced oxidative-nitrosative stress induces inflammation and neurodegeneration via augmented tuberous sclerosis complex-2 (TSC-2) activation in …
Diabetes is a systemic disease mainly characterized by chronic hyperglycemia and with
extensive and long-lasting spiteful complications in central nervous systems (CNS). Astrocytes …
extensive and long-lasting spiteful complications in central nervous systems (CNS). Astrocytes …
TGF-β-regulated collagen type I accumulation: role of Src-based signals
R Mishra, L Zhu, RL Eckert… - American Journal of …, 2007 - journals.physiology.org
Transforming growth factor-β (TGF-β) stimulates myofibroblast transdifferentiation, leading
to type I collagen accumulation and fibrosis. We investigated the function of Src in TGF-β-…
to type I collagen accumulation and fibrosis. We investigated the function of Src in TGF-β-…
[HTML][HTML] Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress
J Fernandez, AB Lopez, C Wang, R Mishra… - Journal of Biological …, 2003 - ASBMB
Cells respond to physiological stress by phosphorylating the α subunit of the translation
initiation factor eIF2. This adaptive response inhibits protein synthesis and up-regulates genes …
initiation factor eIF2. This adaptive response inhibits protein synthesis and up-regulates genes …
Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney
R Mishra, SN Emancipator, C Miller… - American Journal …, 2004 - journals.physiology.org
We investigated the molecular basis of progressive diabetic renal injury in db/db mice by
profiling kidney gene expression. Using high-density microarrays, we identified 482 RNA …
profiling kidney gene expression. Using high-density microarrays, we identified 482 RNA …
[HTML][HTML] Stem cells therapy as a possible therapeutic option in treating COVID-19 patients
D Esquivel, R Mishra, P Soni, R Seetharaman… - Stem cell reviews and …, 2021 - Springer
An unfortunate emergence of a new virus SARS-CoV-2, causing a disease known as COVID-19,
has spread all around the globe and has caused a pandemic. It primarily affects the …
has spread all around the globe and has caused a pandemic. It primarily affects the …
[HTML][HTML] Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy
R Mishra, P Dhawan, AS Srivastava… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), consisting primarily of ulcerative colitis and Crohn’s disease,
is a group of debilitating auto-immune disorders, which also increases the risk of colitis-…
is a group of debilitating auto-immune disorders, which also increases the risk of colitis-…
[HTML][HTML] Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial …
R Mishra, MS Simonson - Cardiovascular diabetology, 2005 - Springer
Background In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but
the phenotypic consequences of FFA accumulation in the microvasculature are incompletely …
the phenotypic consequences of FFA accumulation in the microvasculature are incompletely …