Since the cloning of the histamine H 3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

The histamine H 4 receptor (H 4 R) is involved in the chemotaxis of leukocytes and mast
cells to sites of inflammation and is suggested to be a potential drug target for asthma and …

Nuclear factor κB (NF-κB) is an important transcription factor in inflammation that has obtained
a great interest as a drug target for the treatment of various allergic conditions. In this study…

Previously it was shown that the HHV-8-encoded chemokine receptor ORF74 shows
considerable agonist-independent, constitutive activity giving rise to oncogenic transformation (…

Transient expression of the wild-type human histamine H 1 receptor in SV40-immortalised
African green monkey kidney cells resulted in an agonist-independent elevation of the basal …

G protein–coupled receptors (GPCRs) respond to a chemically diverse plethora of signal
transduction molecules. The notion that GPCRs also signal without an external chemical trigger…

The cloning of the histamine H 3 receptor (H 3 R) cDNA in 1999 by Lovenberg et al. [10]
allowed detailed studies of its molecular aspects and indicated that the H 3 R can activate …

A series of dibenzodiazepine derivatives was synthesized to probe the binding site of the
recently discovered histamine H 4 receptor (H 4 R). Optimization of the lead structure clozapine …

We describe the structure–activity relationships for a series of ligands structurally related to
the recently identified (5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone (1) as …

G protein–coupled receptors (GPCRs) constitute a large and functionally diverse family of
transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to …