Here we report that in skeletal muscle cells the contribution to insulin resistance and
inflammation of two common dietary long-chain fatty acids depends on the channeling of these …

Aims Inflammatory responses in the heart that are driven by sustained increases in cytokines
have been associated with several pathological processes, including cardiac hypertrophy …

Metabolic syndrome-associated dyslipidemia is mainly initiated by hepatic overproduction
of the plasma lipoproteins carrying triglycerides. Here we examined the effects of the …

Objective: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is the predominant
PPAR subtype in cardiac cells and plays a prominent role in the regulation of cardiac lipid …

The mechanisms by which elevated levels of free fatty acids cause insulin resistance are
not well understood. Previous studies have reported that insulin-resistant states are …

Introduction: Prolonged inflammatory response contributes to the pathogenesis of chronic
disease-related disturbances. Among nuclear receptors (NRs), the orphan NR4A subfamily, …

Owing to its high fat content, the classical Western diet has a range of adverse effects on the
heart, including enhanced inflammation, hypertrophy, and contractile dysfunction. …

Metabolic syndrome is defined as the clustering of multiple metabolic abnormalities,
including abdominal obesity, dyslipidemia (high serum triglycerides and low serum HDL-cholesterol …

While the impact of very low concentrations of low–density lipoprotein cholesterol (LDL-C)
on cardiovascular prevention is very reassuring, it is intriguing to know what effect these …

Hypoxia modulates gene expression and affects multiple aspects of endothelial cell biology.
Fibulin-5 (FBLN5) is an extracellular matrix protein essential for elastic fiber assembly and …