All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional
properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-…

Nuclear receptors regulate gene expression by direct activation of target genes and inhibition
of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the …

PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation
of lipid homeostasis, including the metabolism of long-chain fatty acids and conversion of …

Increased activity of lipoprotein lipase (LPL) may explain the hypotriglyceridemic effects of
fibrates, thiazolidinediones and fatty acids, which are known activators (and/or ligands) of the …

An understanding of the differences and similarities of the retinoid X receptor (RXR) and
retinoic acid receptor (RAR) systems requires knowledge of the diversity of their family members…

We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA)
activates transcription in the presence of LXR alpha, a member of the nuclear receptor …

We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of
molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation…

Using a newspaper questionnaire, a door-to-door survey, and 3 laboratory experiments, the
authors examined a proposed effect of shared participation in novel and arousing activities …

Recent studies have shown that genes involved in oxidative phosphorylation (OXPHOS)
exhibit reduced expression in skeletal muscle of diabetic and prediabetic humans. Moreover, …

Retinoic acid receptors (RAR), thyroid hormone receptors (TR), peroxisome proliferator
activated receptors (PPARs) and the orphan receptor, LXR, bind preferentially to DNA as …