Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the
causal agent in chronic myelogenous leukemia. Here we report ten individuals who developed …

Background Sunitinib, a multitargeted tyrosine-kinase inhibitor, which is approved by both
US and European Commission regulatory agencies for clinical use, extends survival of …

During the past decade, emerging evidence has accumulated of different nuclear transcription
factors in regulation of cardiac development and growth as well as in cardiac hypertrophy …

transduction of both extracellular and intracellular signals. Because of their critical role in
normal cellular communication and maintenance of homeostasis, tyrosine kinase activity is …

(BNP), and C-type natriuretic peptide (CNP) are the known members of the mammalian
natriuretic peptide system. The discovery of natriuretic peptides (NPs) dates back to 1981, when …

In overloaded heart the cardiomyocytes adapt to increased mechanical and neurohumoral
stress by activation of hypertrophic program, resulting in morphological changes of individual …

In cells capable of entering the cell cycle, including cancer cells, β-catenin has been termed
a master switch, driving proliferation over differentiation. However, its role as a …

The G protein-coupled apelin receptor regulates important processes of the cardiovascular
homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most …

Congestive heart failure is one of the leading causes of disability in long-term survivors of
cancer. The anthracycline antibiotic doxorubicin (DOX) is used to treat a variety of cancers, but …

Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …