Biophysical constraints of optogenetic inhibition at presynaptic terminals
We investigated the efficacy of optogenetic inhibition at presynaptic terminals using
halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed …
halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed …
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase
A putative endogenous cannabinoid ligand, arachidonylethanolamide (termed “anandamide”),
was isolated recently from porcine brain. Here we demonstrate that this compound is a …
was isolated recently from porcine brain. Here we demonstrate that this compound is a …
[HTML][HTML] Cannabinoids Δ9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-κB and interferon-β/STAT proinflammatory …
…, M Pietr, A Juknat, N Rimmerman, R Levy… - Journal of biological …, 2010 - ASBMB
Cannabinoids have been shown to exert anti-inflammatory activities in various in vivo and
in vitro experimental models as well as ameliorate various inflammatory degenerative …
in vitro experimental models as well as ameliorate various inflammatory degenerative …
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase
Several derivatives of cannabinol and the 1,1-dimethylheptyl homolog (DMH) of cannabinol
were prepared and assayed for binding to the brain and the peripheral cannabinoid …
were prepared and assayed for binding to the brain and the peripheral cannabinoid …
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling
M Bayewitch, T Avidor-Reiss, R Levy, J Barg… - FEBS …, 1995 - Wiley Online Library
Two cannabinoid receptors, designated neuronal (or CB1) and peripheral (or CB2), have
recently been cloned. Activation of CB1 receptors leads to inhibition of adenylate cyclase and N…
recently been cloned. Activation of CB1 receptors leads to inhibition of adenylate cyclase and N…
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis‐like disease in C57BL/6 mice
…, R Eilam, N Rimmerman, R Levy… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Cannabis extracts and several cannabinoids have been
shown to exert broad anti‐inflammatory activities in experimental models of inflammatory CNS …
shown to exert broad anti‐inflammatory activities in experimental models of inflammatory CNS …
[HTML][HTML] High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
…, S Oring, Y Printz, R Levy… - Nature …, 2018 - nature.com
Optogenetic silencing allows time-resolved functional interrogation of defined neuronal
populations. However, the limitations of inhibitory optogenetic tools impose stringent constraints …
populations. However, the limitations of inhibitory optogenetic tools impose stringent constraints …
Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes
…, M Bayewitch, T Avidor‐Reiss, R Levy… - Journal of …, 1998 - Wiley Online Library
Two cannabinoid receptors belonging to the superfamily of G protein‐coupled membrane
receptors have been identified and cloned: the neuronal cannabinoid receptor (CB1) and the …
receptors have been identified and cloned: the neuronal cannabinoid receptor (CB1) and the …
[HTML][HTML] Chronic opioid treatment induces adenylyl cyclase V superactivation: involvement of Gβγ
T Avidor-Reiss, I Nevo, R Levy, T Pfeuffer… - Journal of Biological …, 1996 - ASBMB
It has been known for some time that chronic treatment of neuronal cells and tissues with
opioids, contrary to their acute effect, leads to an increase in cAMP accumulation. This …
opioids, contrary to their acute effect, leads to an increase in cAMP accumulation. This …
[PDF][PDF] Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin
Information is carried between brain regions through neurotransmitter release from axonal
presynaptic terminals. Understanding the functional roles of defined neuronal projection …
presynaptic terminals. Understanding the functional roles of defined neuronal projection …