The identification and characterization of excitotoxic nerve-endings in Alzheimer disease
…, HL Scott, RI Westphalen… - Current Alzheimer …, 2004 - ingentaconnect.com
Regionally specific neuronal loss is a distinguishing feature of Alzheimer disease (AD).
Excitotoxicity is a mechanism commonly invoked to explain this. We review the accumulating …
Excitotoxicity is a mechanism commonly invoked to explain this. We review the accumulating …
Excitotoxic mechanisms in the pathogenesis of dementia
PR Dodd, HL Scott, RI Westphalen - Neurochemistry international, 1994 - Elsevier
Alzheimer disease and related dementias, in common with most major neurological
diseases, are characterized by localized brain damage. An abundance of senile plaques and …
diseases, are characterized by localized brain damage. An abundance of senile plaques and …
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals
RI Westphalen, HC Hemmings - Journal of Pharmacology and Experimental …, 2003 - ASPET
The role of presynaptic mechanisms in general anesthetic depression of excitatory glutamatergic
neurotransmission and facilitation of GABA-mediated inhibitory neurotransmission is …
neurotransmission and facilitation of GABA-mediated inhibitory neurotransmission is …
AGAP1/AP‐3‐dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release
J Bendor, JE Lizardi‐Ortiz, RI Westphalen… - The EMBO …, 2010 - embopress.org
Of the five mammalian muscarinic acetylcholine (ACh) receptors, M 5 is the only subtype
expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release…
expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release…
The general anesthetic isoflurane depresses synaptic vesicle exocytosis
HC Hemmings, W Yan, RI Westphalen, TA Ryan - Molecular pharmacology, 2005 - ASPET
General anesthetics have marked effects on synaptic transmission, but the mechanisms of
their presynaptic actions are unclear. We used quantitative laser-scanning fluorescence …
their presynaptic actions are unclear. We used quantitative laser-scanning fluorescence …
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane
RI Westphalen, KM Desai… - British journal of …, 2013 - academic.oup.com
Background Presynaptic effects of general anaesthetics are not well characterized. We
tested the hypothesis that isoflurane exhibits transmitter-specific effects on neurotransmitter …
tested the hypothesis that isoflurane exhibits transmitter-specific effects on neurotransmitter …
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release
RI Westphalen, HC Hemmings - Journal of Pharmacology and Experimental …, 2006 - ASPET
The effects of three volatile anesthetics (isoflurane, enflurane, and halothane) on basal
release of glutamate and GABA from isolated rat cerebrocortical nerve terminals (synaptosomes) …
release of glutamate and GABA from isolated rat cerebrocortical nerve terminals (synaptosomes) …
Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals
RI Westphalen, HC Hemmings - … Journal of the American Society of …, 2003 - pubs.asahq.org
Background Depression of glutamate-mediated excitatory transmission and potentiation of
gamma-aminobutyric acid (GABA)-mediated inhibitory transmission appear to be primary …
gamma-aminobutyric acid (GABA)-mediated inhibitory transmission appear to be primary …
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release
RI Westphalen, HC Hemmings - Journal of Pharmacology and Experimental …, 2006 - ASPET
Inhibition of glutamatergic excitatory neurotransmission and potentiation of GABA-mediated
inhibitory transmission are possible mechanisms involved in general anesthesia. We …
inhibitory transmission are possible mechanisms involved in general anesthesia. We …
Regional differences in the effects of isoflurane on neurotransmitter release
RI Westphalen, NB Kwak, K Daniels… - …, 2011 - Elsevier
Stimulus evoked neurotransmitter release requires that Na + channel-dependent nerve terminal
depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block …
depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block …