User profiles for Robert Lütjens
 | Robert LutjensCHUV / Addex Verified email at addexpharma.com Cited by 2299 |
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
M Cammalleri, R Lütjens, F Berton… - Proceedings of the …, 2003 - National Acad Sciences
Mammalian target of rapamycin (mTOR) is a key regulator of translational capacity. The mTOR
inhibitor rapamycin can prevent forms of protein synthesis-dependent synaptic plasticity …
inhibitor rapamycin can prevent forms of protein synthesis-dependent synaptic plasticity …
Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10
…, G Di Paolo, SA Stimpson, R Lütjens… - Proceedings of the …, 1997 - National Acad Sciences
Dynamic assembly and disassembly of microtubules is essential for cell division, cell
movements, and intracellular transport. In the developing nervous system, microtubule dynamics …
movements, and intracellular transport. In the developing nervous system, microtubule dynamics …
ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization
Metabotropic glutamate receptor 7 (mGlu 7 ) has been suggested to be a promising novel
target for treatment of a range of disorders, including anxiety, post-traumatic stress disorder, …
target for treatment of a range of disorders, including anxiety, post-traumatic stress disorder, …
Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
…, F Berton, C Simpson, R Lutjens… - Journal of …, 2002 - Soc Neuroscience
Several signal transduction pathways have been implicated in the induction of long-term
potentiation (LTP), yet the signal transduction mechanisms behind the maintenance–…
potentiation (LTP), yet the signal transduction mechanisms behind the maintenance–…
Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation
…, S Mutel, C Hampe, B Breton, V Mutel, R Lütjens - Molecular …, 2012 - ASPET
Activation of G-protein-coupled receptors (GPCRs) results in a variety of cellular responses,
such as binding to the same receptor of different ligands that activate distinct downstream …
such as binding to the same receptor of different ligands that activate distinct downstream …
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its …
…, JI Andrés, FM Dautzenberg, R Lütjens… - … of Pharmacology and …, 2013 - ASPET
Modulation of the metabotropic glutamate type 2 (mGlu2) receptor is considered a promising
target for the treatment of central nervous system diseases such as schizophrenia. Here, we …
target for the treatment of central nervous system diseases such as schizophrenia. Here, we …
Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 …
JM Cid, G Tresadern, G Duvey, R Lutjens… - Journal of Medicinal …, 2014 - ACS Publications
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity
starting from the HTS hit 5. In this article, we describe a different exploration from 5 that led …
starting from the HTS hit 5. In this article, we describe a different exploration from 5 that led …
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction
By using high-density oligonucleotide arrays, we profiled gene expression in reward-related
brain regions of rats that developed escalated cocaine intake after extended access to …
brain regions of rats that developed escalated cocaine intake after extended access to …
ERK regulation in chronic ethanol exposure and withdrawal
The extracellular signal regulated protein kinases (ERKs), also known as mitogen-activated
protein kinases (MAPK) of 42 and 44 kd, play a crucial role in the induction of various forms …
protein kinases (MAPK) of 42 and 44 kd, play a crucial role in the induction of various forms …
Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813
…, JMC Nuńez, S Pype, R Lütjens… - Pharmacology …, 2015 - Wiley Online Library
JNJ‐40411813/ADX71149 (1‐butyl‐3‐chloro‐4‐(4‐phenylpiperidin‐1‐yl) pyridin‐2(1H)‐one)
is a positive allosteric modulator ( PAM ) of the mG lu2 receptor, which also displays 5‐…
is a positive allosteric modulator ( PAM ) of the mG lu2 receptor, which also displays 5‐…