Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by serving
as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an RGS …

The dopamine D3 receptor (D3R) has been implicated in substance abuse and other
neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially …

A series of conformationally-flexible analogues was prepared and their affinities for D2-like
dopamine (D 2 , D 3 and D 4 ) were determined using in vitro radioligand binding assays. …

A series of N-(2-methoxyphenyl)piperazine and N-(2,3-dichlorophenyl)piperazine analogs
were prepared and their affinities for dopamine D 2 , D 3 , and D 4 receptors were measured …

Dopamine D3 receptor subtypes have been hypothesized to play a pivotal role in
modulating the reinforcing and drug-seeking effects induced by cocaine. However, definitive …

Postsynaptic striatal neurodegeneration occurs through unknown mechanisms, but it is
linked to high extracellular levels of synaptic dopamine. Dopamine-mediated cytotoxicity of …

In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH
3 -phenylpiperazine class of compounds with the goal to improve D3 receptor affinity and …

N-(3-Fluoro-4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazine-1-yl)butyl)arylcarboxamides
were prepared and evaluated for binding and function at dopamine D3 receptors (D3Rs) …

Dopamine D3 receptor antagonists and partial agonists have been shown to modulate drug-seeking
effects induced by cocaine and other abused substances. Compound 6 [PG01037, (…

Subtype selective dopamine receptor ligands have long been sought after as therapeutic
and/or imaging agents for the treatment and monitoring of neurologic disorders. We report …