An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype

RL Papke, M Bencherif, P Lippiello - Neuroscience letters, 1996 - Elsevier
The agonist properties of acetylcholine (ACh), tetramethylammonium, ethyl-trimethylammonium
and choline were evaluated for muscle and neuronal nicotinic receptors in Xenopus …

Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis

RL Papke, JK Porter Papke - British journal of pharmacology, 2002 - Wiley Online Library
Pharmacological studies of α7 nicotinic acetylcholine receptors are confounded by the fact
that rapid desensitization to high agonist concentration causes α7 peak responses to occur …

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

DK Williams, J Wang, RL Papke - Biochemical pharmacology, 2011 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug development
in cognitive and neuro-degenerative disorders, are allosteric proteins with dynamic …

Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes

RL Papke, PR Sanberg, RD Shytle - Journal of pharmacology and …, 2001 - ASPET
Because mecamylamine, a nicotinic receptor antagonist, is used so often in nicotine research
and because mecamylamine may have important therapeutic properties clinically, it is …

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

RL Papke, SF Heinemann - Molecular pharmacology, 1994 - ASPET
As previously reported by Luetje and Patrick [J. Neurosci. 11:837-845 (1991)], the nicotine-like
alkaloid cytisine is relatively ineffective in evoking current responses from nicotinic …

Merging old and new perspectives on nicotinic acetylcholine receptors

RL Papke - Biochemical pharmacology, 2014 - Elsevier
This review covers history underlying the discovery of the molecular mediators of nicotine's
effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) subtypes. …

Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal …

…, JC Henry, SI Muraskin, WR Kem, RL Papke - Molecular …, 1995 - ASPET
Investigation of the naturally occurring, nicotinic agonist anabaseine and novel derivatives
has shown that these compounds have cytoprotective and memory-enhancing effects. The …

[HTML][HTML] Nicotinic activity of arecoline, the psychoactive element of" Betel Nuts", suggests a basis for habitual use and anti-inflammatory activity

RL Papke, NA Horenstein, C Stokes - PloS one, 2015 - journals.plos.org
Habitual chewing of "betel nut" preparations constitutes the fourth most common human self-administration
of a psychoactive substance after alcohol, caffeine, and nicotine. The primary …

3-[2, 4-Dimethoxybenzylidene] anabaseine (DMXB) selectively activates rat α7 receptors and improves memory-related behaviors in a mecamylamine-sensitive …

EM Meyer, ET Tay, RL Papke, C Meyers, G Huang… - Brain research, 1997 - Elsevier
The α7 nicotinic receptor agonist 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB; GTS-21)
was investigated for its ability to: (1) activate a variety of nicotinic receptor subtypes in …

Therapeutic targeting of α7 nicotinic acetylcholine receptors

RL Papke, NA Horenstein - Pharmacological Reviews, 2021 - ASPET
The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …