Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer

T Kawamori, R Lubet, VE Steele, GJ Kelloff, RB Kaskey… - Cancer research, 1999 - AACR
Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and
anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, …

[HTML][HTML] Progress in cancer chemoprevention: development of diet-derived chemopreventive agents

GJ Kelloff, JA Crowell, VE Steele, RA Lubet… - The Journal of …, 2000 - Elsevier
Because of their safety and the fact that they are not perceived as “medicine,” food-derived
products are highly interesting for development as chemopreventive agents that may find …

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis

RF Jacoby, K Seibert, CE Cole, G Kelloff, RA Lubet - Cancer research, 2000 - AACR
Epidemiological and animal studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs)
may reduce colon cancer risk. NSAIDs nonselectively inhibit both the constitutive …

Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome (s) P-450 by phenobarbital and other xenobiotics in the rat

RA Lubet, RT Mayer, JW Cameron, RW Nims… - Archives of biochemistry …, 1985 - Elsevier
The O-dealkylation of pentoxyresorufin (7-pentoxyphenoxazone) by rat liver microsomes was
examined. The reaction appeared highly specific for certain phenobarbital inducible forms …

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis

BS Reddy, Y Hirose, R Lubet, V Steele, G Kelloff… - Cancer research, 2000 - AACR
Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …

Chemopreventive activity of celecoxib, a specific cyclooxygenase‐2 inhibitor, and indomethacin against ultraviolet light–induced skin carcinogenesis

…, K Seibert, G Kelloff, RA Lubet… - Molecular …, 1999 - Wiley Online Library
Epidemiological and dietary studies suggest that nonsteroidal anti‐inflammatory drugs (NSAIDs)
reduce the risk of colon cancer, possibly through a mechanism involving inhibition of …

Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation …

…, TG Wood, R Storeng, RA Lubet… - JNCI: Journal of the …, 1990 - academic.oup.com
The major polycyclic aromatic hydrocarbon inducible-cy-tochrome P4501A1 gene (CYP1A1)
is presumed to be important in pulmonary carcinogenesis and toxicology because its …

Lipoxygenase inhibitors as potential cancer chemopreventives

…, CA Holmes, ET Hawk, L Kopelovich, RA Lubet… - … Biomarkers & Prevention, 1999 - AACR
Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound
influence on the development and progression of human cancers. Compared with normal …

Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7, 12-dimethylbenz[a]anthracene …

…, LM Whitaker, GJ Kelloff, VE Steele, RA Lubet - 1996 - academic.oup.com
Curcumin and quercetin were evaluated in rats for their ability to modulate the carcinogenic
activity of azoxy-methane (AOM) in the colon and 7, 12-dimethyl-benz[a]anthracene (DMBA) …

Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats

CJ Grubbs, RA Lubet, AT Koki, KM Leahy, JL Masferrer… - Cancer research, 2000 - AACR
Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may
have a role in the prevention of human cancers. A number of preclinical studies have also …