User profiles for Rosana Alvarez

Rosana Alvarez

Full professor, Universidade Vigo
Verified email at uvigo.es
Cited by 6541

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

…, E Germain, C Ambrosino, P Bontempo, R Alvarez… - Nature medicine, 2005 - nature.com
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific
gene expression. Altered chromatin function can lead to aberrant expression of growth …

Functions, therapeutic applications, and synthesis of retinoids and carotenoids

R Alvarez, B Vaz, H Gronemeyer, AR de Lera - Chemical reviews, 2014 - ACS Publications
Vitamin A (all-trans-retinol, 1, Figure 1) is considered the most multifunctional vitamin in the
human body. 1 It plays key roles in many physiological processes such as vision, …

Palladium‐Catalyzed Intermolecular C(sp3)H Amidation

A Iglesias, R Alvarez, AR de Lera, K Muniz - … Chemie International Edition, 2012 - infona.pl
Dual capacity: A new palladium‐catalyzed intermolecular sequence consisting of the CH
activation and amidation of methyl groups relies on N‐fluorobis(phenylsulfonyl)imide (NFSI) …

C− C reductive elimination in palladium complexes, and the role of coupling additives. A DFT study supported by experiment

…, G Ujaque, AR De Lera, R Alvarez… - Journal of the …, 2009 - ACS Publications
A DFT study of R−R reductive elimination (R = Me, Ph, vinyl) in plausible intermediates of Pd-catalyzed
processes is reported. These include the square-planar tetracoordinated systems …

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

…, A Ardèvol, M Domínguez, R Alvarez… - Proceedings of the …, 2007 - National Acad Sciences
AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer
types and in precancerous lesions. In vitro, AKR1B10 exhibits a much higher retinaldehyde …

Mechanism of the gold (I)-catalyzed Rautenstrauch rearrangement: A center-to-helix-to-center chirality transfer

ON Faza, CS López, R Álvarez… - Journal of the American …, 2006 - ACS Publications
The mechanism of the stereospecific gold(I)-catalyzed Rautenstrauch rearrangement of (E)-1-ethynyl-2-methyl-but-2-en-yl
acetate to 3,4-dimethyl-cyclopent-2-enone has been …

A General Synthesis of Alkenyl‐Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium‐Catalyzed Heterocyclization/Oxidative Heck Coupling

R Álvarez, C Martínez, Y Madich… - … A European Journal, 2010 - Wiley Online Library
Structurally diverse C3‐alkenylbenzofurans, C3‐alkenylindoles, and C4‐alkenylisoquinolones
are efficiently prepared by using consecutive Sonogashira and cascade Pd‐catalyzed …

Palladium-catalyzed sequential oxidative cyclization/coupling of 2-alkynylphenols and alkenes: a direct entry into 3-alkenylbenzofurans

C Martinez, R Alvarez, JM Aurrecoechea - Organic Letters, 2009 - ACS Publications
A new Pd-catalyzed tandem intramolecular oxypalladation/Heck-type coupling between 2-alkynylphenols
and alkenes is reported, leading to 3-(1-alkenyl)benzofurans. Participating …

Macroscale plasmonic substrates for highly sensitive surface‐enhanced Raman scattering

…, P Granero, J Ferré‐Borrull, R Alvarez… - Angewandte Chemie …, 2013 - Wiley Online Library
The fabrication of macroscale optical materials from plasmonic nanoscale building blocks is
the focus of much current multidisciplinary research. In these macromaterials, the nanoscale …

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

S Alvarez, P Germain, R Alvarez… - The international journal …, 2007 - Elsevier
Only one of the three-retinoic acid receptors, RARβ, is frequently deleted or epigenetically
silenced at early stages in tumor progression and there is compelling evidence that RARβ …