Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological
processes including hepatic gluconeogenesis, lipid metabolism, circadian rhythm, and …

The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ (NR1F3))
are orphan nuclear receptors and perform critical roles in regulation of development, …

The vitamin D receptor (VDR) functions as an obligate heterodimer in complex with the
retinoid X receptor (RXR). These nuclear receptors are multidomain proteins, and it is unclear …

10.7554/eLife.02057.001 Resveratrol has beneficial effects on aging, inflammation and
metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1)…

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the
master regulator of adipogenesis and the pharmacological target of the thiazolidinedione (TZD) …

Regulation of nuclear receptor (NR) activity is driven by alterations in the conformational
dynamics of the receptor upon ligand binding. Previously, we demonstrated that hydrogen/…

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late
2019 has triggered an ongoing global pandemic whereby infection may result in a lethal …

Insulin-degrading enzyme (IDE) is a ubiquitous zinc-metalloprotease that hydrolyzes
several pathophysiologically relevant peptides, including insulin and the amyloid β-protein (Aβ). …

The orphan nuclear receptor RORγ is a key regulator for T helper 17 (T H 17) cell differentiation,
which regulates metabolic and circadian rhythm genes in peripheral tissues. Previously, …

The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining
transcription factor to initiate the differentiation program of T H 17 and T C 17 cells, cells that …