Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs).
Drugs targeting this pathway are used clinically, but tumor resistance invariably …

Schweinfurthins are potent inhibitors of cancer cell growth, especially against human central
nervous system tumor lines such as SF-295 cells. However, the mechanisms through which …

Schweinfurthins are intriguing natural products with anti-cancer activities and as yet
incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein …

Context National licensing exams (NLEs) including the Comprehensive Osteopathic Medical
Licensing Examination (COMLEX) Level 1 evaluate student achievement. Scores have …

… Author links open overlay panel Niall Sheehy FFRRCSI a , Stephanie Ford FFRRCSI a ,
Ronan McDermott FFRRCSI a , Vincent Young FRCS b , Mark Ryan FFRRCSI a …

Schweinfurthins are intriguing natural product anti-cancer agents with incompletely defined
mechanisms of action. Schweinfurthins increase ER stress and result in apoptosis in vitro. To …

Schweinfurthins are potent inhibitors of cancer cell growth especially against human-derived
central nervous system (CNS) tumor lines, such as the SF-295 cells. However, the …

Accurate diagnostic testing is at the center of controlling infectious disease outbreaks. It allows
clinicians and public health practitioners to identify and treat infected individuals as well …

Lung cancer is the leading cause of cancer-related deaths in the United States with a 5-year
survival rate of 18% leaving room for improvement in non-invasive diagnosis and treatment …

… ‘firstspace’ practices if we want to change space in a strategic way (Sheehy Citation2009). …
requires specific pedagogic intervention to do well (Ryan Citation2010a), a programme-wide …