The synthesis of thymidylate (TMP) occupies a convergence of two critical metabolic
pathways: folate metabolism and pyrimidine biosynthesis. Thymidylate is formed from …

… James Bray and Sandra Berger conducted part of this research while they were affiliated
with Texas Woman's University—Houston Center. This research was supported by Grants RO1 …

Rochelle salt (RS)(Na KC 4 H 4 O 6∙ 4 H 2 O) single crystals were grown inside an array of
alumina pores having an average diameter of 30 nm and length of about 0.5 μ m. The crystals …

Thymidylate synthase (TS) is the target in colon cancer therapeutic protocols utilizing such
drugs as 5-fluorouracil and raltitrexed. The effectiveness of these treatments is hampered by …

Thymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and
some other neoplasms while raltitrexed (Tomudex, ZD1694) is an antifolate inhibitor of TS …

Cytotoxicity to 5-fluoro-2'-deoxyuridine (FdUrd) derives from its conversion to 5-fluorodeoxyuridine-5'-monophosphate,
which binds to and inhibits thymidylate synthase (TS) in the …

Objectives: Brush cytology has a low sensitivity for the diagnosis of cholangiocarcinoma.
This study aimed to compare the standard approach (brush cytology) with a triple modality …

Thymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and
some other neoplasms. The emergence of resistance to the treatment is often related to the …

Breast cancer is the most commonly diagnosed cancer among women, 1 and risk increases
substantially with age. 2 It is the second leading cause of cancer death among women in …

Germ‐line mutation of the Apc gene has been linked to familial adenomatous polyposis (FAP)
that predisposes to colon cancer. Apc Min/+ mice, heterozygous for the Apc gene mutation…