[HTML][HTML] Hierarchical organization of calcium signals in hepatocytes: from experiments to models

G Dupont, S Swillens, C Clair, T Tordjmann… - … et Biophysica Acta (BBA …, 2000 - Elsevier
The proper working of the liver largely depends on the fine tuning of the level of cytosolic Ca
2+ in hepatocytes. Thanks to the development of imaging techniques, our understanding of …

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

…, L Montanelli, T Loy, M Bonomi, S Swillens… - The EMBO …, 2005 - embopress.org
The monomeric model of rhodopsin‐like G protein‐coupled receptors (GPCRs) has
progressively yielded the floor to the concept of GPCRs being oligo(di)mers, but the functional …

Mechanism of receptor‐oriented intercellular calcium wave propagation in hepatocytes

G Dupont, T Tordjmann, C Clair, S Swillens… - The FASEB …, 2000 - Wiley Online Library
… After cell plating, the medium was removed and replaced with a William’s medium E
containing 3 … 45 s at low levels of stimulation which, in the model, leads to a latency of 70 s. …

[PDF][PDF] Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis.

S Swillens - Molecular pharmacology, 1995 - Citeseer
Typical equilibrium binding experiments cannot be quantitatively analyzed on the basis of
classical mathematical equations when the receptor concentration is so high that a significant …

Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional …

J Parma, J Van Sande, S Swillens… - Molecular …, 1995 - academic.oup.com
A series of somatic mutations of the TSH receptor gene have been demonstrated in
hyperfunctioning thyroid adenomas. The mutations studied up to now cause constitutive (ie TSH-…

From calcium blips to calcium puffs: theoretical analysis of the requirements for interchannel communication

S Swillens, G Dupont, L Combettes… - Proceedings of the …, 1999 - National Acad Sciences
… We find that Republican members of Congress who supported President Trump’s “stop the
… between condoning or opposing Donald Trump’s efforts to overturn the 2020 presidential …

Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA

L Mercken, MJ Simons, S Swillens, M Massaer… - Nature, 1985 - nature.com
In mammals, an adequate supply of thyroid hormones is essential for normalgrowth and
neurological development. The biosynthesis of thyroid hormones involves an iodinated …

Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission

P d'Alcantara, C Ledent, S Swillens, SN Schiffmann - Neuroscience, 2001 - Elsevier
… In LTP experiments, the conditioning tetanus consisted in three successive trains (1 s
duration, 100 Hz frequency, at 10 s intervals). For all experiments, data were filtered at 1 kHz, …

Thyroperoxidase, an auto‐antigen with a mosaic structure made of nuclear and mitochondrial gene modules.

F Libert, J Ruel, M Ludgate, S Swillens… - The EMBO …, 1987 - embopress.org
A lambda gt11 cDNA library was constructed from a normal human thyroid and screened with
a rabbit anti‐porcine thyroperoxidase antibody. A series of thyroperoxidase (TPO) clones …

Instant evaluation of the absolute initial number of cDNA copies from a single real‐time PCR curve

S Swillens, JC Goffard, Y Marechal… - Nucleic acids …, 2004 - academic.oup.com
… A two‐step PCR procedure was used, 60 s at 60C and 15 s at 95C for 50 cycles in a PCR
mix containing 2 µl of cDNA template, 1× qPCR Mastermix (RT‐QP2X‐03, Eurogentec), 300 …