Sodium channels in normal and pathological pain

SD Dib-Hajj, TR Cummins, JA Black… - Annual review of …, 2010 - annualreviews.org
Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na v 1.1–Na v 1.9, are …

The NaV1.7 sodium channel: from molecule to man

SD Dib-Hajj, Y Yang, JA Black… - Nature Reviews …, 2013 - nature.com
The voltage-gated sodium channel Na V 1.7 is preferentially expressed in peripheral
somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion …

The role of voltage-gated sodium channels in pain signaling

…, J Huang, SG Waxman, SD Dib-Hajj - Physiological …, 2019 - journals.physiology.org
Acute pain signaling has a key protective role and is highly evolutionarily conserved. Chronic
pain, however, is maladaptive, occurring as a consequence of injury and disease, and is …

NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy

SD Dib-Hajj, L Tyrrell, JA Black… - Proceedings of the …, 1998 - National Acad Sciences
Although physiological and pharmacological evidence suggests the presence of multiple
tetrodotoxin-resistant (TTX-R) Na channels in neurons of peripheral nervous system ganglia, …

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

SD Dib-Hajj, AM Rush, TR Cummins, FM Hisama… - Brain, 2005 - academic.oup.com
Erythromelalgia is an autosomal dominant disorder characterized by burning pain in
response to warm stimuli or moderate exercise. We describe a novel mutation in a family with …

[PDF][PDF] A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons

TR Cummins, SD Dib-Hajj, JA Black… - The Journal of …, 1999 - Soc Neuroscience
… 3) and is expressed preferentially in small sensory neurons (Dib-Hajj et al., 1998), we …
is accompanied by a decrease in NaN mRNA levels (Dib-Hajj et al., 1998; Tate et al., 1998). …

[PDF][PDF] De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP

…, JE O'Brien, MH Meisler, X Cheng, SD Dib-Hajj… - The American Journal of …, 2012 - cell.com
Individuals with severe, sporadic disorders of infantile onset represent an important class of
disease for which discovery of the underlying genetic architecture is not amenable to …

Gain-of-function Nav1.8 mutations in painful neuropathy

…, R Lombardi, D Kapetis, SD Dib-Hajj… - Proceedings of the …, 2012 - National Acad Sciences
Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-function
variants of sodium channel Na v 1.7 have recently been found in ∼30% of cases of …

A single sodium channel mutation produces hyper-or hypoexcitability in different types of neurons

AM Rush, SD Dib-Hajj, S Liu… - Proceedings of the …, 2006 - National Acad Sciences
Disease-producing mutations of ion channels are usually characterized as producing
hyperexcitability or hypoexcitability. We show here that a single mutation can produce …

Electrophysiological properties of mutant Nav1. 7 sodium channels in a painful inherited neuropathy

TR Cummins, SD Dib-Hajj… - Journal of Neuroscience, 2004 - Soc Neuroscience
Although the physiological basis of erythermalgia, an autosomal dominant painful neuropathy
characterized by redness of the skin and intermittent burning sensation of extremities, is …