Distinct mechanism for antidepressant activity by blockade of central substance P receptors
…, G Liu, D Snavely, E Wyatt-Knowles, JJ Hale, SG Mills… - Science, 1998 - science.org
The localization of substance P in brain regions that coordinate stress responses and receive
convergent monoaminergic innervation suggested that substance P antagonists might …
convergent monoaminergic innervation suggested that substance P antagonists might …
Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent …
JJ Hale, SG Mills, M MacCoss, PE Finke… - Journal of medicinal …, 1998 - ACS Publications
Structural modifications requiring novel synthetic chemistry were made to the morpholine
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…
Selective small-molecule agonists of G protein–coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
…, M Einstein, S Kumar, JP Berger, SG Mills… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free fatty acids
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter …
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter …
Potent 1, 3, 4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties
…, CL Lynch, RJ Budhu, M MacCoss, SG Mills… - Bioorganic & medicinal …, 2005 - Elsevier
… Mills a , Lorraine Malkowitz b , Sandra L. Gould b , Julie A. DeMartino b , Martin S. …
Shah, CL Lynch, JJ Hale, SG Mills, KT Chapman, L. Malkowitz, MS Springer, SL Gould, JA …
Shah, CL Lynch, JJ Hale, SG Mills, KT Chapman, L. Malkowitz, MS Springer, SL Gould, JA …
Nectar resource use by Colias butterflies: Chemical and visual aspects
WB Watt, PC Hoch, SG Mills - Oecologia, 1974 - Springer
Nectar foraging preferences of Colias butterflies in two different mountain ecosystems are
examined with respect to plant distribution, nectar quantity, carbohydrate (and amino acid) …
examined with respect to plant distribution, nectar quantity, carbohydrate (and amino acid) …
Chemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (-)-FK-506
…, RA Reamer, R Desmond, SG Mills - Journal of the American …, 1990 - ACS Publications
Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are
presented, and their use in designing a successful route to this immunosuppressant is outlined. …
presented, and their use in designing a successful route to this immunosuppressant is outlined. …
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3
Z Li, W Chen, JJ Hale, CL Lynch, SG Mills… - Journal of medicinal …, 2005 - ACS Publications
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent
sphingosine-1-phosphate-1 (S1P 1 ) receptor agonists with minimal affinity for the S1P 2 and …
sphingosine-1-phosphate-1 (S1P 1 ) receptor agonists with minimal affinity for the S1P 2 and …
The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in …
…, G Mason, S Tye, DJ Williamson, JJ Hale, SG Mills… - …, 2000 - Elsevier
The anti-emetic profile of the novel brain penetrant tachykinin NK 1 receptor antagonist MK–0869
(L–754,030) 2–(R)–(1–(R)–(3,5–bis(trifluoromethyl)phenylethoxy)–3–(S)–(4–fluoro)…
(L–754,030) 2–(R)–(1–(R)–(3,5–bis(trifluoromethyl)phenylethoxy)–3–(S)–(4–fluoro)…
Total synthesis of immunosuppressant (-)-FK-506
TK Jones, SG Mills, RA Reamer, D Askin… - Journal of the …, 1989 - ACS Publications
FK-506 (1), isolated from Streptomyces tsukubaensis (No. 9993), 1 is a unique 21-member
macrolide that possesses excep-tional biological activity and an array of challenging …
macrolide that possesses excep-tional biological activity and an array of challenging …
Solvent effects on keto-enol equilibria: tests of quantitative models
SG Mills, P Beak - The Journal of Organic Chemistry, 1985 - ACS Publications
… Mills and Peter Beak* … Mills and Beak … Mills and Beak …