Allosteric regulation plays an important role in many biological processes, such as signal
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental …

The presence of globular sub-structures within proteins has long been recognized. The
description of the X-ray structure of hen l ysozyme by Phillips (1966) and that of the protease …

The function of nearly all proteins is mediated by their interaction with partners that are small
molecules or, very often, other biological macromolecules: proteins, DNA, and RNA. Protein-…

Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem affinity …

In this paper we present SFCHECK, a stand-alone software package that features a unified
set of procedures for evaluating the structure-factor data obtained from X-ray diffraction …

Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited. …

… Shoshana Wodak and her coworkers accepted the role of assessors. This included collecting
the predictions, establishing and calculating all quality measures used in the evaluation, …

Standard ranges of atomic and residue volumes are computed in 64 highly resolved and
well-refined protein crystal structures using the classical Voronoi procedure. Deviations of the …

Gold standard datasets on protein complexes are key to inferring and validating protein–protein
interactions. Despite much progress in characterizing protein complexes in the yeast …

The current status of docking procedures for predicting protein–protein interactions starting
from their three‐dimensional structure is assessed from a first major evaluation of blind …