Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in
primary afferent neurons. N-type calcium channels are localized to synaptic nerve terminals …

Neuronal nicotinic acetylcholine receptors (nAChRs) have been a target for drug discovery
efforts, primarily for CNS indications, for the past two decades. While nicotine and related …

Although the molecular biology of neuronal nicotinic acetylcholine receptors (nAChRs)
provides evidence for multiple receptor subtypes, few selective pharmacological tools exist to …

Several lines of evidence suggest a link between the α7 neuronal nicotinic acetylcholine
receptor (nAChR) and brain disorders including schizophrenia, Alzheimer's disease, and …

Importance It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are
at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent …

Development of analgesic agents for the treatment of severe pain requires the identification
of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant = 37 …

Presenilins are integral membrane protein involved in the production of amyloid β-protein.
Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease …

The present study describes substantial, selective, age-related loss of the putative inhibitory
neurotransmitter GABA in the central nucleus of the inferior colliculus (CIC) of rat based on …

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a
novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been …

… site point, and the sp 3 nitrogen atom and its complementary site point, whereas the
second omitted the requirement for the site point complementary to the sp 3 nitrogen. …