Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation
of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis …

Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma
longa). Curcumin has a surprisingly wide range of beneficial properties, including …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the …

BACKGROUND: Serum ferritin was discovered in the 1930s, and was developed as a
clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. …

During inflammation, NF-κB transcription factors antagonize apoptosis induced by tumor
necrosis factor (TNF)α. This antiapoptotic activity of NF-κB involves suppressing the …

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a
wide range of physiologic and pathologic processes. In clinical medicine, ferritin is …

Iron is required for normal cell growth and proliferation. However, excess iron is potentially
harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton …

Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis.
Ferroportin is the only known mechanism for export of intracellular non–heme-associated …

Ferritin is a spherical molecule composed of 24 subunits of two types, ferritin H chain (FHC)
and ferritin L chain (FLC). Ferritin stores iron within cells, but it also circulates and binds …