Reactions that enable carbon–nitrogen, carbon–oxygen and carbon–carbon bond formation
lie at the heart of synthetic chemistry. However, substrate prefunctionalization is often …

The development of a gold(I)‐catalyzed sulfination of aryl boronic acids is described. This
transformation proceeds through an unprecedented mechanism which exploits the reactivity of …

A mild, efficient synthesis of sulfonyl fluorides from aryl and heteroaryl bromides utilizing
palladium catalysis is described. The process involves the initial palladium-catalyzed …

Carboxylic acids are valuable building blocks for pharmaceutical discovery because of their
chemical stability, commercial availability, and structural diversity. Decarboxylative coupling …

Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized
diabetes therapy, but their use has been limited because they require injection. Herein, we …

A series of low‐molecular‐weight, compact, and multifunctional cyclic alkenylsulfonyl
fluorides were efficiently prepared from the corresponding alkenyl triflates. Palladium‐catalyzed …

Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2
diabetes mellitus (T2DM), hepatic steatosis, and cancer. However, the identification of tool …

Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous
acid. Clinical evidence suggests a causal role for MPO in various autoimmune and …

Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4,
a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of …

We report the successful manufacture of several >50 kg batches of a key intermediate via a
Birch reduction that utilized liquified ammonia as well as lithium metal. With an eye toward …