… Although the total [Ca 2+ ] in the SR is important to the overall functional size of the Ca 2+
store, many aspects of Ca 2+ store’s operation are determined by free rather than total luminal …

… Györke: Regulation of calcium release by calcium inside the sarcoplasmic reticulum in
ventricular myocytes. Pflugers Arch432, 1047-1054 (1996) 25. Satoh, H., LA Blatter & DM …

… conditions, luminal Ca 2+ acts by interacting with the cytosolic activation site of the channel
and suggest that the effects of luminal Ca 2+ are mediated by distinct Ca 2+ -sensitive site(s) …

The level of Ca inside the sarcoplasmic reticulum (SR) is an important determinant of functional
activity of the Ca release channel/ryanodine receptor (RyR) in cardiac muscle. However, …

… That is, although oxidative modification(s) appear(s) to be a major causal factor in abnormal
RyR2 function in our particular HF model, our results do not exclude the possibility that …

MicroRNAs are small endogenous noncoding RNAs that regulate protein expression by
hybridization to imprecise complementary sequences of target mRNAs. Changes in abundance …

… less frequent in CSQs myocytes (0.57 ± 0.16 s –1 , n = 92) and more frequent in CSQas
myocytes (3.87 ± 0.09 s –1 , n = 336), as compared with control (2.11 ± 0.07 s –1 , n = 253). In …

… tween UV flashes by stirring the medium for 30 s. We generated … s) closely correlates with
the rate of Ca2+-dependent inactivation measured in permeablized cardiacmyocytes (T = 1.1 S…

… In addition to increased oxidation, reductions in S-nitrosylation of RyR2s has also been
observed in the failing cardiomyocytes. Physiological S-nitrosylation, whose baseline level is …

Diminished Ca release from the sarcoplasmic reticulum (SR) is an important contributor to
the impaired contractility of the failing heart. Despite extensive effort, the underlying causes of …