Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers

S McCavera, TK Walsh, AJ Wolstenholme - Parasitology, 2007 - cambridge.org
Ligand-gated chloride channels, including the glutamate-(GluCl) and GABA-gated channels,
are the targets of the macrocyclic lactone (ML) family of anthelmintics. Changes in the …

An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus

S McCavera, AT Rogers, DM Yates, DJ Woods… - Molecular …, 2009 - ASPET
… before perfusion through the oocyte chamber for 5 to 10 s. A washing period of 5 min was
allowed … The cells were further disrupted by sonication in three 10-s bursts on medium power. …

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

…, C Rada, E Bailey, S McCavera… - EMBO molecular …, 2014 - embopress.org
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including
preterm birth, dysfunctional labour and post‐partum haemorrhage. Uterine contractile …

Differential state-dependent modification of inactivation-deficient Nav1. 6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin

SJ McCavera, DM Soderlund - Neurotoxicology, 2012 - Elsevier
… repeated channel activation, and S-bioallethrin modification is … By contrast modification by
S-bioallethrin following short … of deltamethrin and tefluthrin (but not S-bioallethrin) to Na v 1.6…

Music: Striking the right notes

S McCavera - British Journal of Special Education, 1991 - Wiley Online Library
… Again, the provision for music is resourced in a variety of ways, both from the school’s
own staff and from external groups. Music is seen as an essential ingredient in the school’s

A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1

…, C McCloskey, S McCavera… - Journal of …, 2015 - journals.sagepub.com
… MRT00200769’s potential as a therapeutic is limited by its hERG activity, which we were
unable to reduce in our initial medicinal chemistry. Of uppermost importance, however, was the …

[PDF][PDF] An invermectin sensitive ion channel from haemonchus contortus

SJC McCavera - 2008 - core.ac.uk
… Finally I would like to thank my parents, Peter and Trish McCavera and my sister Fiona,
who, without a doubt, are my greatest source of strength and inspiration. It was their belief that I …

Assessing the validity and accuracy of online videos on vaccine health risks

M Murphy, FA Nanadiego, L McCavera… - Clinical …, 2020 - journals.sagepub.com
… Several factors that affect any particular patient’s response to immunization may include, but
… Therefore, videos that insinuated or insisted that an individual patient’s suffering strongly …

A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors

T Lynagh, JW Lynch - International journal for parasitology, 2010 - Elsevier
… In this experiment, we repeatedly applied ∼1 s applications of a constant EC 10 –EC 20
glycine concentration that alternated with 4 s applications of progressively increasing ivermectin …

Altered avr-14B gene transcription patterns in ivermectin-resistant isolates of the cattle parasites, Cooperia oncophora and Ostertagia ostertagi

A El-Abdellati, J De Graef, A Van Zeveren… - International journal for …, 2011 - Elsevier
… Single-stranded template DNA was isolated using the designated Vacuum Prep Tool (Biotage)
according to the manufacturer’s instructions and added to 40 μl of sequencing primer (…