Theta, a new class of glutathione transferases purified from rat and man

DJ Meyer, B Coles, SE Pemble, KS Gilmore… - Biochemical …, 1991 - portlandpress.com
Glutathione transferases (GSTs) of a novel class, which it is proposed to term Theta, were
purified from rat and human liver. Two, named GST 5-5 and GST 12-12, were obtained from …

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

S Pemble, KR Schroeder, SR Spencer… - Biochemical …, 1994 - portlandpress.com
… prepared from total RNA using the method described by Pemble et al. (1986) and was used
… Control reactions using primers for the GST class Mu processed psuedogene (S. Pemble, …

Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

SE PEMBLE, AF WARDLE, JB TAYLOR - Biochemical Journal, 1996 - portlandpress.com
We have isolated a cDNA clone that encodes rat glutathione S-transferase (GST) subunit 13,
a GST originally isolated from rat liver mitochondrial matrix by Harris, Meyer, Coles and …

The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer.

…, G Talaska, DJ Meyer, SE Pemble… - Environmental …, 1992 - ehp.niehs.nih.gov
Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes
capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of …

An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences

SE Pemble, JB Taylor - Biochemical journal, 1992 - portlandpress.com
We report the cDNA sequence for rat glutathione transferase (GST) subunit 5, which is one of
at least three class Theta subunits in this species. This sequence, when compared with that …

Correlation of clinical and molecular features in spinal bulbar muscular atrophy

…, I Skorupinska, T Collins, A Cortese, S Pemble… - Neurology, 2014 - AAN Enterprises
Objectives: To characterize the clinical and genetic features of spinal bulbar muscular atrophy
(SBMA), a rare neurodegenerative disorder caused by the expansion of a CAG repeat in …

Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.

JK Wiencke, S Pemble, B Ketterer, KT Kelsey - … epidemiology, biomarkers & …, 1995 - AACR
Genetic traits that confer increased susceptibility to DNA and chromosomal damage from
reactive epoxide and peroxides could be important individual risk factors in the development of …

[HTML][HTML] The role of interruptions in polyQ in the pathology of SCA1

…, S Faggiano, T Vannocci, H Rezaei, S Pemble… - PLoS …, 2013 - journals.plos.org
At least nine dominant neurodegenerative diseases are caused by expansion of CAG repeats
in coding regions of specific genes that result in abnormal elongation of polyglutamine (…

The structure of the human glutathione S-transferase π gene

IG Cowell, KH Dixon, SE Pemble, B Ketterer… - Biochemical …, 1988 - portlandpress.com
The human glutathione S-transferase pi gene has been isolated from a cosmid library. The
gene spans approximately 3 kb, is interrupted by six introns and the region around its 5′ …

The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni.

…, C Southan, P Sondermeyer, S Pemble… - The EMBO …, 1988 - embopress.org
A protective Mr28K antigen of Schistosoma mansoni, expressed from its cDNA, has been
purified in a single step and shown to possess glutathione (GSH) transferase activity as …