… Simon’s specialisation is the implementation of change programmes in large, complex …
Little’s experiences in developing sustainability indicators and exploring two case studies where …

G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled
receptors in drug discovery. CRC Press; 2006] are the single largest drug target, …

… 1b), we see that both the hydroxyl and amino groups of Corazolol’s alkylamine form hydrogen
bonds with both Asp113 and Asn312. The nitrogen atom of Corazolol’s carbazole moiety …

… The Src homology (SH2) domain of Grb2 binds preferentially to phosphotyrosines (Y*s) with
the sequence motif Y*XNX. The two SH3 domains of Grb2 bind to Sos, which catalyzes GTP/…

… The details of the orthosteric ligand ’s binding, including the involvement of residues from
the extracellular loops, were seen in these first examples as well as in various functional …

… The largest differences in relative energies and dipole moments of our AMI geometry
optimizations from the correspondingvalues of Norinder’s study are 0.3 kcal/mol and 0.31 D, …

A general criterion is formulated for molecular recognition. The criterion for recognition is
the ineqality of the distance matrices of complexes of different compounds with a resolving …

… We explore the utility of the Beta2-adrenergic receptor’s X-ray structure in drug design
including high-throughput docking. Results validate the approach and project its usefulness in …

… Well-known examples of SSRIs on the market are escitalopram (S-citalopram, also an
allosteric serotonin reuptake inhibitor (ASRI);1 trade names Cipralex, Lexapro), fluoxetine, …

Introduction: In 2007, the X-ray structural determination of non-rhodopsin G-Protein coupled
receptors (GPCRs), considered the most extensively targeted protein class for marketed …